Abstract
Neurodegenerative disease Alzheimer’s disease (AD) is attracting growing concern because of an increasing patient population among the elderly. Tea consumption is considered a natural complementary therapy for neurodegenerative diseases. In this paper, epidemiological studies on the association between tea consumption and the reduced risk of AD are reviewed and the anti-amyloid effects of related bioactivities in tea are summarized. Future challenges regarding the role of tea in preventing AD are also discussed.
Highlights
Alzheimer’s disease (AD) is progressive neurodegenerative disorder pathologically characterized by deposition of β-amyloid (Aβ) peptides as senile plaques in the brain and its prevalence is strongly correlated with aging [1]
The action-based memory of people with dementia of AD can be judged by looking at the process of preparing a cup of tea
The culture medium from epigallocatechin gallate (EGCG)-treated astrocytes facilitated the degradation of exogenous Aβ, suggesting that EGCG may have a beneficial effect on persons with AD by activating extracellular signal-regulated kinase (ERK)- and PI3K-mediated pathways in astrocytes, thereby increasing astrocyte secretion of neutral endopeptidase (NEP) and facilitating degradationofAβ [80]
Summary
Alzheimer’s disease (AD) is progressive neurodegenerative disorder pathologically characterized by deposition of β-amyloid (Aβ) peptides as senile plaques in the brain and its prevalence is strongly correlated with aging [1]. Along with other neurodegenerative dementias diseases, AD lacks any effective cure. For this reason, the prevention of AD and non-pharmacological treatments are important research [7]. Tea consumption is considered to be one simple lifestyle adjustment that may either prevent or treat the cognitive declines associated with neurodegenerative AD [10,11]. (1) the neurodegenerative process in AD is characterized by the presence of cerebral extracellular deposition of Aβ and the published reviews rarely focused on the anti-Aβ effects of tea. The most significant research advances regarding tea’s potential role in the prevention and treatment of AD and other related neurodegenerative symptoms were included in the present review by searching the Web of Science database using keywords “tea”. “Alzheimer’s disease” and the cited references were updated until February 2018
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