Abstract
Background: Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been reported to be strongly associated with type 2 diabetes mellitus (T2DM) in Icelandic, Danish and American populations and further replicated in other European populations, African Americans, Mexican Americans, and Asian populations. The aim of the present study was to investigate the association of TCF7L2 gene polymorphisms with T2DM in a Uygur population of China. Methods: 877 T2DM patients and 871 controls were selected for the present study. Two single nucleotide polymorphisms (SNPs) (rs12255372 and rs7901695) were genotyped by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. The associations of SNPs and haplotypes with T2DM and linkage disequilibrium (LD) structure of the TCF7L2 gene were analyzed. Results: For total participants and male, the distribution of rs12255372 alleles and the dominant model (Guanine Guanine (GG) genotype vs. Guanine Thymine (GT) genotype + Thymine Thymine (TT) genotype) showed significant difference between T2DM and control subjects (for allele: p = 0.013 and p = 0.002, respectively; for dominant model: p = 0.028 and p = 0.008, respectively). The distribution of rs7901695 alleles and the dominant model (TT genotype vs. Thymine Cytosine (TC) genotype + Cytosine Cytosine (CC) genotype) for total participants and male showed significant difference between T2DM and control subjects (for allele: both p = 0.001; for dominant model: p = 0.006 and p = 0.008, respectively). Conclusions: Our data suggested that the genetic polymorphisms of the TCF7L2 gene were associated with T2DM in the Uygur population of China.
Highlights
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by chronic hyperglycemia resulting from the combination of genetic and environmental factors [1].Most individuals with type 2 diabetes mellitus (T2DM) suffer various complications, such as coronary heart disease, diabetic nephropathy, neuropathy and retinopathy
Body mass index (BMI), systolic blood pressure (SBP), the serum concentration of glucose, total cholesterol (TC), and BUN were significantly higher for T2DM patients than for control subjects (p < 0.05), whereas the serum concentration of HDL-C, LDL-C, and uric acid (UA) were significantly lower for
There was no significant difference in the following variables between T2DM patients and control subjects: age, diastolic blood pressure (DBP), the serum concentration of TG, creatinine
Summary
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by chronic hyperglycemia resulting from the combination of genetic and environmental factors [1].Most individuals with T2DM suffer various complications, such as coronary heart disease, diabetic nephropathy, neuropathy and retinopathy. Several genetic variants have shown association with T2DM among different ethnic populations. In 2006, Grant et al [6] identified one microsatellite DG10S478 within intron 3 of the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (p = 2.1 × 10−9) in Icelandic individuals. This association was replicated in a Danish cohort (p = 4.8 × 10−3) and in a US cohort (p = 3.3 × 10−9). The associations of SNPs and haplotypes with T2DM and linkage disequilibrium (LD) structure of the TCF7L2 gene were analyzed
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