Abstract
The association between T174M polymorphism of angiotensinogen gene and essential hypertension risk remains controversial. We herein performed a meta-analysis to achieve a reliable estimation of their relationship. All the studies published up to May 2013 on the association between T174M polymorphism and essential hypertension risk were identified by searching the electronic repositories PubMed, MEDLINE and EMBASE, Springer, Elsevier Science Direct, Cochrane Library and Google Scholar. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Ultimately, nine eligible studies, including 2188 essential hypertension cases and 2459 controls, were enrolled in this meta-analysis. No significant associations were found under the overall ORs for M-allele comparison (M vs. T, pooled OR 0.92, 95% CI 0.62-1.37), MM vs. TT (pooled OR 0.86, 95% CI 0.29-2.51), TM vs. TT n (pooled OR 0.91, 95% CI 0.63-1.32), recessive model (MM vs. TT+TM, pooled OR 0.89, 95% CI 0.35-2.30), dominant model (MM+TM vs. TT, pooled OR 0.91, 95% CI 0.60-1.38) between T174M polymorphism and risk for essential hypertension. This meta-analysis suggested that the T174M polymorphism of the angiotensinogen gene might not be associated with the susceptibility of essential hypertension in Asian or European populations.
Highlights
Hypertension affects approximately 30% of adults in industrialized countries and is the major risk factor for cardiovascular disease (Nguyen et al, 2013)
The remaining 40 studies were examined in detail by full text review, this leading to the exclusion of 31 articles, including 17 publications that not about the T174M gene and 14 for not showing available data
The association between the T174M polymorphism and risk for essential hypertension was not clear due to inconsistent data generated by a range of independent studies (Nair et al, 2003; Tsai et al, 2003; Jiang et al, 2009; Nejatizadeh et al, 2008)
Summary
Hypertension affects approximately 30% of adults in industrialized countries and is the major risk factor for cardiovascular disease (Nguyen et al, 2013). Hypertension is classified into essential hypertension and secondary hypertension according to the etiology. More than 90% of all hypertensive persons are reported to have essential hypertension (Ghosh et al, 2013). Essential hypertension is associated with large and small vascular remodeling that impacts cardiovascular prognosis (Briet and Schiffrin, 2013). It is generally considered as a paradigmatic multi-factors disease which involves a combination of genetic factors, environmental stimuli and their interaction (O’Shaughnessy, 2001). It has been reported that approximately 20-60% of the inter-individual variation in blood pressure is genetically controlled (Kurtz and Spence, 1993). We hypothesized that exploring potential hypertension susceptibility genes would help us to better understand the etiology of the disease and, eventually, to better control this disease
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