Abstract
Diabetes mellitus (DM) is a disease entity associated with metabolic abnormality and systemic vascular inflammation, causing microvascular as well as macrovascular organ damage. Statins are widely used for the management of dyslipidemia. Beyond the lipid-lowering effect, statins were found to have many pleiotropic effects, such as anti-inflammatory and antiatherogenic effects. We conducted a nationwide population-based cohort study to investigate the relationship between statin use and the risk of lower-extremity amputation in patients with DM. A database from the Taiwan National Health Research Institutes was used, and subjects with DM were identified using ICD-9 coding. The study cohort was separated to statin group and control groups. The observation end point was any lower-extremity amputation. Out of a total of 38,973 patients with DM, 20,254 (51.97%) patients taking statins were compared with those not taking statins. During a mean follow-up of 5.2 …
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