Abstract
Statins inhibit cholesterol synthesis but may also up-regulate cholesterol absorption. Studies evaluating markers of cholesterol metabolism suggest that cholesterol-lowering treatment efficacy may be the greatest with maximal inhibition of synthesis and limited compensatory increases in absorption. Ezetimibe is a selective cholesterol absorption inhibitor that also increases markers of cholesterol synthesis. Co-administration of ezetimibe with statins produces complementary effects and significantly greater reductions in LDL-C lowering than either drug alone.
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