Abstract

Objectives: To determine frequency of left main stem (LMS) and triple vessel coronary artery disease (3VCAD) in patients of Non-ST-elevation myocardial infarction (NSTEMI) and to compare the frequency of LMS and 3VCAD in patients with NSTEMI with or without ST elevation in lead aVR. Methodology: Total 346 patients with NSTEMI having age 30-70 years were included in this descriptive cross-sectional study. The data on demographic details was collected. All patients underwent electrocardiography (ECG) and cardiac specific troponin-I assessment. Patients were categorized as NSTEMI with or without ST-elevation in lead aVR. Coronary angiography was performed in all patients and angiographic findings were noted. Results: Mean age of patients was 51.87±10.03 years. There were 218 (63.01%) males and 128 (36.99%) female patients. 182 (52.60%) patients of NSTEMI had ST elevation in aVR. LMS disease was found in 53 (29.10%) patients with ST elevation in aVR. Sensitivity, specificity, positive predive value and negative predictive value of ST elevation in aVR for LMS disease was 62.35%, 50.57%, 29.12% and 80.49% respectively. 3 VCAD was found in 54 (29.70%) with ST elevation in aVR. Sensitivity, specificity, positive predive value and negative predictive value of ST elevation in aVR for 3VCAD was 77.14%, 53.52%, 29.67% and 90.24% respectively. Conclusion: NSTEMI patients with ST elevation in aVR may have higher chances of having LMS disease or 3VCAD. There is high negative predictive value for ST elevation in aVR to predict LMS disease or 3VCAD.

Highlights

  • The patients with Non-ST elevation myocardial infarction (NSTEMI) have variable degree of severity of coronary artery disease and prognosis.[1]

  • Triple vessel disease was found in 46.5 % patients with ST elevation in aVR compared to 26.1% with no ST-elevation in aVR.[9]

  • Considering the literature, the rationale of our study is to find out the diagnostic value of ST elevation in aVR with left main stem (LMS) disease or 3VCAD for the patients with NSTEMI

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Summary

Introduction

The patients with Non-ST elevation myocardial infarction (NSTEMI) have variable degree of severity of coronary artery disease and prognosis.[1]. The lead aVR is often ignored in clinical practice.[5] different studies have shown that ST elevation in lead aVR can predict adverse events in NSTEMI patients more accurately.[6,7] ST elevation in aVR is a simple and an easy indicator of left main stem (LMS) or triple vessel disease (3VCAD) and can guide for the triage of these highrisk patients.[6,8] Yan AT et al showed that among 5064 patients with NSTEMI 5.8% had minor (0.5-1 mm) ST elevation in aVR, and 1.5% had major (>1 mm) ST elevation in aVR. Triple vessel disease was found in 46.5 % patients with ST elevation in aVR compared to 26.1% with no ST-elevation in aVR.[9]

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