Association of some hemostasis and endothelial dysfunction factors with probability of presence of vulnerable atherosclerotic plaques in patients with coronary atherosclerosis

Yu I Ragino,E V Kashtanova,A M Volkov,I S Murashov,Ya V Polonskaya,A M Chernjavskii,E V Striukova,A V Kurguzov

doi:10.1186/s13104-019-4360-7

Abstract

ObjectiveThe study was dedicated to investigation of some hemostasis and endothelial dysfunction factors association with probability of presence of vulnerable atherosclerotic plaques in coronary arteries in men with atherosclerosis.ResultsThe blood levels of factor VII, factor XII and MCP-1 were higher, and concentration of sVCAM-1 lower in men with vulnerable atherosclerotic plaques in the coronary arteries, compared to men who had stable plaques. Have been revealed correlation links between the blood levels of factor II, factor XII, MCP-1 and the presence of vulnerable atherosclerotic plaques in the coronary arteries. Results of logistic regression analysis showed that the relative risk of present of vulnerable atherosclerotic plaques in the coronary arteries is associated with an elevated blood level of factor XII and MCP-1.

Highlights

Cardiovascular diseases are one of the main causes of mortality in Russia and in the world
The endothelial dysfunction and oxidative changes of lipoproteins are known to play an important role at the initial stage of atherosclerotic plaque formation, while at the stage of vulnerable plaque formation the activity of inflammatory and destructive processes is pronounced [1, 3–5]
On the 1st stage of our investigation we revealed increase of factor VII and XII levels in patients with vulnerable plaques reflecting the intrinsic and extrinsic coagulation pathway

Summary

Results

The blood levels of factor VII, factor XII and MCP-1 were higher, and concentration of sVCAM-1 lower in men with vulnerable atherosclerotic plaques in the coronary arteries, compared to men who had stable plaques. Have been revealed correlation links between the blood levels of factor II, factor XII, MCP-1 and the presence of vulnerable atherosclerotic plaques in the coronary arteries. Results of logistic regression analysis showed that the relative risk of present of vulnerable atherosclerotic plaques in the coronary arteries is associated with an elevated blood level of factor XII and MCP-1

Introduction

Main text

Discussion

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