Association of soluble ST-2 and galectin-3 with new onset atrial fibrillation after ventricular septal myectomy in patients with hypertrophic cardiomyopathy

Abstract

Objective We aimed to explore the association between soluble ST-2 and galectin-3 (Gal-3) levels and new onset atrial fibrillation after ventricular septal myectomy in patients with hypertrophic cardiomyopathy (HCM) . Methods One hundred seventy consecutive HCM patients who underwent ventricular septal myectomy in Fuwai Hospital from March 2011 to February 2016 were enrolled. Demographics, clinical characteristics and echocardiographic parameters of these patients were collected. Soluble ST-2 and Gal-3 levels were examined by Enzyme-linked immunosorbent assay (ELISA) . The association of these parameters with new onset postoperative atrial fibrillation (POAF) were assessed. Results POAF was documented in 16 patients in hospital. POAF patients were older[ (49.8±9.6) years vs. (42.1±14.2) years, P=0.036]and had more smoking (62.5% vs. 38.3%, P=0.047) . Soluble ST-2 [9.0 (7.3-22.2) ng/ml vs. 12.6 (8.7-18.0) ng/ml, P=0.37]and Gal-3[7.2 (6.2-9.9) ng/ml vs. 7.1 (5.4-8.7) ng/ml, P=0.45]in patients with POAF were similar to that in those without POAF. In multivariable regression analysis, age (odds ratio 1.065, 95% CI 1.007-1.126, P=0.028) was an independent predictor of POAF. Conclusion Plasma soluble ST-2 and Gal-3 levels were not associated with the occurrence of POAF in patient with HCM who underwent ventricular septal myectomy. Advanced age might be an independent predictor of POAF in HCM patients after surgical ventricular septal myectomy. Key words: Atrial fibrillation; Soluble ST-2; Galectin-3