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Abstract
Abstract To investigate the association between allograft inflammatory factor-1 (AIF-1) gene polymorphism and susceptibility to oral cancer in Chinese population. A case-control study was conducted to collect 400 cases of newly diagnosed oral cancer patients diagnosed by pathology from January 2015 to June 2019 and 400 cases of physical examination in the same period. Single nucleotide polymorphisms (SNPs) of the AIF-1 gene were detected using TaqMan probe technology. Unconditional logistic regression analysis was used to calculate the odd ratios (OR) and 95% confidence interval (CI) of the association between AIF-1 gene polymorphism and oral cancer susceptibility. GG genotypes reduced the risk of oral cancer in co-dominant models (OR = 0.499, 95% CI: 0.328-0.760, P = 0.001) and recessive models (OR = 0.496, 95% CI: 0.342-0.729, P < 0.001). There was no significant difference between the case group and the control group in the dominant model genotype (OR = 0.836, 95% CI: 0.623~1.121, P = 0.836). Conclusion AIF-1 gene rs2857595 gene SNPs can reduce the risk of oral cancer.
Highlights
Head and neck cancer can occur in the paranasal sinuses, sinuses, nasopharynx, oropharynx, mouth, pharynx, and throat
Practical Application: In the future, the AFS-1 gene rs2857595 locus GG genotype should be considered in the development of precise prevention strategies and measures for oral cancer
The results of a genome-wide association study (GWAS) by Wei et al (2014) suggest that single nucleotide polymorphisms (SNPs) of the rs2857595 locus of the allograft inflammatory factor-1 (AIF-1) gene are associated with the susceptibility of laryngeal squamous cell carcinoma (LSCC) in Chinese population
Summary
Head and neck cancer can occur in the paranasal sinuses, sinuses, nasopharynx, oropharynx, mouth, pharynx, and throat. The treatment of head and neck cancer often causes problems such as pain, diet and communication, which seriously affects the mental health of patients (Devins et al, 2013; Sreekumar, 2019). The results of a genome-wide association study (GWAS) by Wei et al (2014) suggest that single nucleotide polymorphisms (SNPs) of the rs2857595 locus of the AIF-1 gene are associated with the susceptibility of laryngeal squamous cell carcinoma (LSCC) in Chinese population. Effective head and neck cancer markers have been found to play a key role in understanding tumor causes, patient outcomes, and in-depth research. This study used a case-control study to explore the association between AIF-1 gene SNPs and susceptibility to oral cancer, and to provide a scientific basis for the development of accurate prevention strategies and measures for oral cancer
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