Abstract
Objective:To determine the association of SNP in FTO gene, rs9939609, with Metabolic Syndrome (MS) in type 2 diabetic subjects at a tertiary care unit of Karachi, Pakistan.Methods:We genotyped FTO rs9939609 SNP in 296 patients with type 2 diabetes from the Out Patient Department (OPD) of Baqai Institute of Diabetology and Endocrinology (BIDE). MS was defined on the basis of International Diabetes Federation (IDF) and National Cholesterol Education program (NCEP) criterion. Association between the rs9939609 SNP and MS was tested through chi-square and Z-tests by using odds ratio (OR) with 95% confidence intervals.Results: The frequency of MS as defined by IDF criterion was significantly higher in female subjects as compared to male subjects (p= 0.006). Carriers of ≥ 1 copy of the rs9939609 A allele were significantly more likely to had MS (69.6%) than non-carriers (30.4%), corresponding to a carrier odds ratio (OR) of 0.52 (95% confidence interval [CI] (0.29-0.93), with a similar trend for the ATP III-defined MS.“A” allele carriers under dominant model, carry all the criterion of MS more significantly as compared to non-carriers.Conclusion:The FTO rs9939609 SNP was associated with an increased risk for Metabolic Syndrome in type 2 diabetic populations at a tertiary care unit of Karachi, Pakistan.
Highlights
Metabolic Syndrome (MS), is defined as a constellation of potential risk factors like obesity, hypertension, hyperglycemia, dyslipidemia and insulin resistance
No significant difference was found on the basis of central obesity as defined by International Diabetes Federation (IDF) while with ATP III criterion, female subjects were significantly more centrally obese as compared to male subjects (p < 0.0001)
Studies from Asia and from South East Asia reported the association of FTO gene with obesity and associated risk factors.[1,3]
Summary
Metabolic Syndrome (MS), is defined as a constellation of potential risk factors like obesity, hypertension, hyperglycemia, dyslipidemia and insulin resistance. It is a global health problem and a substantial economic burden for both developing Correspondence. September 29, 2014 September 30, 2014 October 3, 2014 October 25, 2014 November 1, 2014 and developed countries.[1] MS escalates the risk of development in patients with type 2 diabetes by five times and doubles the risk of cardiovascular diseases.[2]. The data from Pakistan showed a prevalence rate of 18%-46% while 46%-75% Pakistani patients with diabetes were found to have MS.4,5Although obesity and MS do not completely overlap, obesity is considered the core of MS.[3]
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