Abstract
Six prostate cancer (PCa) susceptibility loci were identified in a genome-wide association study (GWAS) in populations of European decent. However, the associations of these 6 single-nucleotide polymorphisms (SNPs) with PCa has remained tobe clarified in men in Northern China. This study aimed to explore the loci associated with PCa risk in a Northern Chinese population. Blood samples and clinical information of 289 PCa patients and 288 controls from Beijing and Tianjin were collected. All risk SNPs were genotyped using polymerase chain reaction (PCR)-high resolution melting curve technology and gene sequencing. Associations between PCa and clinical covariates (age at diagnosis, prostate-specific antigen [PSA], Gleason score, tumor stage, and level of aggressiveness) and frequencies of alleles and genotypes of these SNPs were analyzed using genetic statistics. Among the candidate SNPs, 11p15 (rs7127900, A) was associated with PCa risk (P = 0.02, odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.09-2.46). Genotypes showed differences between cases and controls on 11p15 (rs7127900, A), 11q13 (rs7931342, T), and HNF1B (rs4430796, A) (P = 0.03, P = 0.01, and P = 0.04, respectively). The genotype TG on 11q13 (rs7931342, T) was positively associated with an increased Gleason score (P = 0.04, OR = 2.15, 95% CI = 1.02-4.55). Patients carrying TG on 17q24 (rs1859962, G) were negatively associated with an increased body mass index (BMI) (P = 0.03, OR = 0.44, 95% CI = 0.21-0.92) while those with AG on HNF1B (rs4430796, A) were more likely to have PSA increase (P = 0.002). Our study suggests that 11p15 (rs7127900, A) could be a susceptibility locus associated with PCa in Northern Chinese. Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.
Highlights
Prostate cancer (PCa) is one of the most common cancers affecting men worldwide
Allele frequencies were tested between cases and control subjects; 11p15 showed a significant difference (P = 0.02, Odds ratios (ORs) = 1.64, 95% confidence intervals (CIs) = 1.09–2.46)
Patients carrying TG on 17q24 were negatively associated with an increased body mass index (BMI) (P = 0.03, OR = 0.44, 95% CI = 0.21–0.92)
Summary
Prostate cancer (PCa) is one of the most common cancers affecting men worldwide. It has different morbidity rates in different countries. A genome-wide association study (GWAS) found at least 35 loci related to PCa (Sun et al, 2008; Thomas et al, 2008). Testing of these risk alleles across populations is important (Waters et al, 2009). Study of the PCa risk loci distribution in Northern Chinese populations could increase clinical understanding of the PCa genetic etiology. This study aimed to exam the 6 risk loci (MSMB, rs10993994, T; 11p15, rs7127900, A; 11q13, rs7931342, T; HNF1B, rs4430796, A; 17q24, rs11859962, G; KLK2, rs2735839, A) associated with PCa risk in Northern Chinese populations
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