Association of SH2B1 gene polymorphism with overweight and obesity

Abstract

To investigate the association of SH2B1 gene rs7359397 polymorphism with overweight and obesity, as well as some related metabolic indicators in Northwest Chinese. Based on the cohort of China National Diabetes and Metabolic disorders Study(2007-2008)in Shanxi province, totally 1 210(including 635 overweight and 167 obese)males and 1 711(including 781 overweight and 212 obese)females were participated in this study. Matrix assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS)was adopted as the genotyping method. After adjusting for age, the single nucleotide polymorphism rs7359397 of SH2B1 was found to be associated with overweight and obesity in males. The correlation with overweight accords with the dominant(P=0.02), overdominant(P=0.03), and log-additive models(P=0.025), while the correlation with obesity accords with the dominant(P=0.007 8), overdominant(P=0.008 1), and log-additive models(P=0.015). rs7359397 showed to have a significant association with body mass index, body fat percentage, fasting serum insulin, homeostasis model assessment of insulin resistance in males; and high density lipoprotein-cholesterol in females(P<0.05). The results show that SH2B1 rs7359397 polymorphism is associated with overweight, obesity, and related metabolic indicators in males of the population studied. (Chin J Endocrinol Metab, 2017, 33: 1038-1042) Key words: Single nucleotide polymorphism; Overweight; Obesity; SH2B1 gene; Insulin