Association of serum vitamin-D level with renal function in a rural population of Bangladesh

Abstract

Background: Vitamin D deficiency is an emerging global health problem. Recent studies have indicated that the prevalence of vitamin D deficiency even in tropical countries is as high as that observed in Western populations. Vitamin D deficiency has high impact on renal disorders which are leading causes of death in humans.
 Methods: This was a cross sectional analytical study. According to inclusion criteria of the study total 259 participants were recruited from a rural area, Baidyerbazar union of Narayanganj district. After taking history and clinical examination, relevant investigations were done. Serum 25(OH)D was measured using chemiluminescent immunoassay (CLIA) technology (DiaSorin Inc, Stillwater, MN). Renal functions of the study population were assessed by e-GFR (calculated by CKD-EPI equation), urinary ACR and urine microscopy.
 Results: In this study out of 259 study subjects on vitamin-D status 6.2%, 33.6% and 60.2% had vitamin-D sufficiency, insufficiency and deficiency respectively. Among participated female (133) 78.2% had vitamin-D deficiency and among participated male (126) 41.3% had vitamin-D deficiency. Among vitamin-D sufficiency, insufficiency and deficiency group the mean eGFR was 102.94, 104.87 and 109.33 ml/min/1.73 m2 respectively. The mean uACR level was 6.97, 22.89 and 37.29 mg/gm respectively.
 Conclusion: The findings of the study suggest that 93.8% of study population had either vitamin-D insufficiency or deficiency. Vitamin-D deficiency was more prevalent in females than males. Serum 25- hydroxyvitamin D level was negatively associated with urinary ACR level.
 Mugda Med Coll J. 2022; 5(2): 82-87