Abstract
BackgroundAlthough previous studies reported an association between serum vitamin D and parathyroid hormone (PTH) with carotid atherosclerosis or arterial stiffness, these were inconsistent. We examined the independent association between serum vitamin D and PTH with multiple subclinical markers of atherosclerosis.MethodsA total of 8,217 subjects who participated in the Dong-gu Study in Korea were included in the final analysis. The carotid artery structure, including intima-media thickness (IMT), plaques, and luminal diameter, was evaluated using a high-resolution B-mode ultrasound. The brachial-ankle pulse wave velocity (baPWV) was determined using an automatic waveform analysis device, and the mean of the left and right baPWV was used.ResultsThe PTH concentration was positively associated with carotid luminal diameter and baPWV, but not with carotid IMT and plaques. The mean carotid luminal diameter of individuals with PTH levels in the second, third, and fourth quartiles was significantly larger compared with those in the first quartile (P-trend < 0.01). The mean baPWV of individuals with PTH levels in the fourth quartile was significantly greater than those with PTH levels in the first quartile (P-trend = 0.01). However, there was no significant association between vitamin D and any atherosclerotic phenotypes, including carotid IMT, plaques, luminal diameter, and baPWV.ConclusionThis suggests that PTH might affect the development of atherosclerosis by altering vascular compliance.
Highlights
Numerous epidemiological studies have demonstrated associations between lower serum vitamin D and higher parathyroid hormone (PTH) concentrations with cardiovascular events and deaths [1,2,3,4,5,6]
The PTH concentration was positively associated with carotid luminal diameter and brachial-ankle pulse wave velocity (baPWV), but not with carotid intima-media thickness (IMT) and plaques
There was no significant association between vitamin D and any atherosclerotic phenotypes, including carotid IMT, plaques, luminal diameter, and baPWV
Summary
Numerous epidemiological studies have demonstrated associations between lower serum vitamin D and higher parathyroid hormone (PTH) concentrations with cardiovascular events and deaths [1,2,3,4,5,6]. Several explanations for the relationships between serum vitamin D, PTH, and cardiovascular disease have been presented, the underlying mechanisms remain unclear. One possible explanation is that atherosclerosis might mediate a link between serum vitamin D, PTH and cardiovascular disease (CVD). Previous studies reported an association between serum vitamin D and parathyroid hormone (PTH) with carotid atherosclerosis or arterial stiffness, these were inconsistent. We examined the independent association between serum vitamin D and PTH with multiple subclinical markers of atherosclerosis
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