Abstract
Aims: Evidence linking serum uric acid (sUA) and bone mineral density (BMD) in adolescents is very limited. To the best of our knowledge, only one report has focused on the relationship between sUA and BMD in adolescents. Thus, this study aimed to determine the association between sUA and total BMD in adolescents aged 12–19 years.Methods: A cross-sectional study was conducted on a sample composed of non-institutionalized US population from the National Health and Nutrition Examination Survey. Weighted multivariate linear regression models were used to evaluate the association between sUA and total BMD. Subgroup analyses were further performed.Results: sUA positively correlated with total BMD in the multiple regression model after adjusting for potential confounders. However, in the subgroup analyses stratified by sex, age, or race/ethnicity, the association between sUA and total BMD followed an inverted U-shaped curve in female adolescents, adolescents aged 16–19 years, and other race/ethnicity.Conclusions: Our results suggested that the correlation between sUA level and total BMD differed by sex. The increased sUA level would be beneficial to bone health in adolescents with low sUA levels, but for female adolescents, a higher sUA level (turning point, 3.9 mg/dL) may have an adverse effect on bone health.
Highlights
During adolescence, bone accumulates and grows at a rapid rate
On-going studies are assessing the correlation of bone health with some less studied or novel biomarkers, such as serum uric acid
In the fully-adjusted model, we observed a positive association between serum uric acid (sUA) and total Bone mineral density (BMD) [0.0076 (0.0056, 0.0097)] (Table 2, Figure 1)
Summary
Bone accumulates and grows at a rapid rate. Bone mineral density (BMD) acquisition during this period is critical for bone mass accrual and skeletal formation to acquire a greater peak bone mass and prevent osteoporosis at older age [1, 2]. Clinical evaluation of osteoporosis-associated risk factors contributes to early diagnosis, prevention, and management of osteoporosis. On-going studies are assessing the correlation of bone health with some less studied or novel biomarkers, such as serum uric acid (sUA). Convincing experimental studies reported that antioxidants could contribute to the reduction of osteoclast activity and the activation of osteoblasts [3, 4]. Reactive oxygen species could reduce the bone formation activity of osteoblasts and simultaneously stimulate the resorption
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