Abstract
ObjectiveTo date, no study in the published literature has investigated the role of various serum uric acid (SUA) concentrations in the development of angiographically-proven coronary artery disease (CAD) in premenopausal women. Therefore, the aim of this study was to investigate the role SUA levels may play in the prevalence, severity, and prognosis of CAD in premenopausal women.MethodsThis cross-sectional retrospective study included 607 premenopausal women who had undergone coronary angiography. The CAD diagnosis was based upon stenosis affecting ≥50% of the luminal diameter. Association of the SUA levels with CAD prevalence, severity, and clinical outcomes were assessed by statistical analysis.ResultsIn total, 369 (60.8%) of the patients were diagnosed with CAD. The CAD patients had significantly higher SUA levels than those without CAD (5.3±1.9 vs. 4.8±1.7 mg/dL, P = 0.001). The SUA levels were found to be significantly associated with CAD prevalence (P = 0.013). Patients with higher levels of SUA also showed increased rates of multivessel disease and composite end-points, such as major adverse cardiac events. Furthermore, multivariate analysis identified abnormally high levels of uric acid (hyperuricemia) as an independent risk factor for CAD (OR 1.51 (1.11–2.53), P<0.05).ConclusionsThe SUA levels are significantly associated with the prevalence of CAD. The SUA levels may be a predictor for incidence of major cardiovascular events in premenopausal women.
Highlights
Menopausal women are at a greater risk of developing coronary artery disease (CAD) than their premenopausal counterparts, a result of the loss of hormone protection that accompanies menopause [1,2,3]
Due to the scarcity of data available for premenopausal women diagnosed with CAD, little is known of the characteristics, mechanism, prognosis, and risk factors of these patients
Recent studies have demonstrated an independent association between serum uric acid (SUA) and CAD [6,7]
Summary
Menopausal women are at a greater risk of developing coronary artery disease (CAD) than their premenopausal counterparts, a result of the loss of hormone protection that accompanies menopause [1,2,3]. Hyperuricemia, an abnormally high level of uric acid in the blood, was identified as a novel risk factor for the development of CAD [5]. Recent studies have demonstrated an independent association between serum uric acid (SUA) and CAD [6,7]. Several studies have demonstrated a strong association of SUA levels with cardiovascular disease (CVD) in women, as compared with their male counterparts [5,8,9]. These studies, did not evaluate the relationship between levels of SUA and incidence of CAD in premenopausal women. Our study was designed to investigate the role SUA may play in the prevalence, severity, and prognosis of CAD in premenopausal women
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