Abstract
5015^ Background: Factors influencing efficacy of ABI in suppressing SR and TX androgens and inhibiting tumor growth in PCa are unknown. We examined the relationship of SR and TX ABI levels with SR and TX steroid levels and pathologic responses. Methods: Steroid and ABI levels were measured by mass spectrometry in SR and TX from 58 men with localized PCa in a clinical trial of castration with 3 or 6 months (mo) of ABI prior to prostatectomy. Results: Median ABI levels in SR and TX were 31 ng/ml (range 2.8-414) and 18 pg/mg (1.3-265) respectively. SR and TX ABI levels were positively correlated with SR and TX steroids upstream of CYP17A (pregnenolone [Preg], progesterone [Prog]) and inversely correlated with downstream steroids (17OH Preg, DHEA, all p<0.05). Two men at 3 mo and six at 6 mo had undetectable ABI in SR and TX, and did not show changes in steroids up or downstream of CYP17A. In men with undetectable vs detectable TX ABI levels, there was a trend toward higher cross-sectional tumor dimension, T...
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