Abstract
Introduction: Dialysis patients tend to have a greater prevalence of cardiovascular diseases. Objectives: The aim of this study was to determine the prevalence of heart valve calcification, left ventricular hypertrophy, and left ventricular systolic and diastolic dysfunction. It also aimed to determining the relationship of the above mentioned parameters with serum calcium, phosphorus, parathormon and duration of dialysis. Patients and Methods: This cross-sectional study was conducted on 100 hemodialysis patients who were referred to Hajar hospital in Shahrekord, Iran. Using echocardiography, patients were examined for the calcification of the heart valves, left ventricular hypertrophy, and left ventricular systolic and diastolic dysfunction. Serum calcium, phosphorus, and parathormon and duration of dialysis was also determined. Results: The mean age of the patients was 58.10 ± 15.51 years. Around 24 patients suffered from calcification of the heart valves. Additionally, 85 patients suffered from left ventricular hypertrophy. The prevalence of left ventricular systolic and diastolic dysfunction was 26% and 86%, respectively. Common valvular abnormalities were mitral valve regurgitation (97%), followed by tricuspid regurgitation and aorta-pulmonary disorder, respectively. There was a significant relationship between serum phosphate and calcification of cardiac valves, left ventricular hypertrophy, and left ventricular systolic dysfunction (P 0.05). Conclusion: Cardiovascular diseases are common among hemodialysis patients. Hyperphosphatemia is a risk factor for the prevalence of left ventricular hypertrophy, left ventricular systolic dysfunction and calcification of the heart valves.
Highlights
Chronic renal failure (CRF) is an irreversible decline of renal function which leads to end-stage renal disease (ESRD)
No significant relationship of serum calcium and parathyroid hormone, with left ventricular hypertrophy; a significant relationship of serum phosphorus and left ventricular hypertrophy was detected (Table 2)
We investigated the prevalence of echocardiographic findings in hemodialysis patients including calcification of cardiac valves, valvular disease, left ventricular systolic and diastolic dysfunction, and left ventricular hypertrophy in hemodialysis patients admitted to our hospital in Shahrekord
Summary
Chronic renal failure (CRF) is an irreversible decline of renal function which leads to end-stage renal disease (ESRD). This condition is associated with renal replacement therapy including dialysis or transplantation [1]. The annual rate of mortality from cardiovascular diseases in hemodialysis patients is around 9%, which is 30 times higher than that in general population [2]. Other factors that are related to hemodialysis patients and increase the rates of cardiovascular disease, included stress on myocardium caused by increased intravascular volume load, increase or decrease of trace elements that act as enzymatic factors and factors that inhibit myocardial ATPase [3,4]. The reduction of 1,25-dihydroxyvitamin D and calcium in the serum will
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