Abstract
BackgroundWhereas a few studies have reported associations of serum omentin levels with subclinical atherosclerosis in patients with diabetes, little information is available with respect to the associations of serum omentin levels and diabetic microvascular complications. The aim of this study was to investigate the relationships of serum omentin levels and vascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM).MethodsWe recruited 97 patients who evaluated complications of diabetes. CAN was assessed by five standard cardiovascular reflex tests according to Ewing’s protocol. Diabetic nephropathy (DN), retinopathy (DR), and peripheral neuropathy (DPN) were evaluated. Serum omentin levels were assessed by ELISA. Atherosclerotic burden was evaluated by measuring the brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI).ResultsThe prevalence of CAN increased borderline significantly across the omentin tertiles (p = 0.05) and CAN point increased significantly and progressively across the omentin tertiles (p = 0.013). The prevalence of other microvascular complications (DPN, DN, and DR) did not differ among omentin tertiles. The mean levels of baPWV also increased significantly and progressively across the omentin tertiles (p = 0.002). Serum omentin levels were significantly positively correlated with CAN point (p = 0.004) and borderline significantly correlated with baPWV (p = 0.05) after multivariate adjustment. Regarding linear regression analysis for CAN point, univariate regression analysis demonstrated that CAN point associated with omentin, diastolic blood pressure (DBP) and hsCRP. Multiple regression analysis revealed that omentin levels, together DBP and baPWV correlated with CAN point. This present study suggests that serum omentin levels may be independently associate with CAN in patients with T2DM.
Highlights
Whereas a few studies have reported associations of serum omentin levels with subclinical atheroscle‐ rosis in patients with diabetes, little information is available with respect to the associations of serum omentin levels and diabetic microvascular complications
In the present study, we examined the relationship among serum omentin levels, subclinical atherosclerosis markers, and microvascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM)
We found that serum omentin levels did not differ between patients with and without each microvascular complication
Summary
Whereas a few studies have reported associations of serum omentin levels with subclinical atheroscle‐ rosis in patients with diabetes, little information is available with respect to the associations of serum omentin levels and diabetic microvascular complications. The aim of this study was to investigate the relationships of serum omentin levels and vascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). The known effects of omentin include insulin-sensitizing and, anti-inflammatory activities beneficial to vascular health. Serum levels of omentin were reported to be reduced during dysmetabolic states [5,6,7]. Contradictory results have been reported regarding the association of serum omentin with the above-mentioned metabolic risk factors [12, 13]
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