Association of serum Ninjurin2 levels with neurologic damage and postherpetic neuralgia occurrence: an observational cohort study in chinese herpeszoster patients.

Guozhuan Zhang,Yingjiao Sun,Hui Tian,Lishuang Liang,Lei Wang

doi:10.18632/oncotarget.17640

Guozhuan Zhang, Yingjiao Sun + Show 3 more

Open Access

https://doi.org/10.18632/oncotarget.17640

Copy DOI

Journal: Oncotarget	Publication Date: May 4, 2017
Citations: 5	License type: cc-by

Affiliation: Qilu Hospital of Shandong University

Abstract

ObjectivesPostherpetic neuralgia(PHN) is the most common complication of herpeszoster (HZ) infection. The study aimed to explore whether serum Ninjurin2 (for nerve injury-induced protein 2, NINJ2), a novel neurologic damage related protein, is associated with nerve injury and the occurrence of PHN.ResultsSeventy-four of the eighty patients completed the study. On the 7th day of AHN, the patients had significantly higher values of NINJ2, cold-sense dispersion (ΔCS), warm-sense dispersion (ΔWS), cold-pain dispersion (ΔCP), heat-pain dispersion (ΔHP) and NRS score compared to controls. Six months after herpes, thirty four patients developed PHN. The values of serum NINJ2, ΔCS, ΔWS, ΔCP and ΔHP in PHN patients remained higher than in the controls and the patients who did not develop PHN. The PHN patients had significantly lower values of serumNINJ2 than patients who did not develop PHN in the period of AHN. With partial correlations and multivariable logistic regressions, serum NINJ2 level was strongly predictive of PHN.Materials and MethodsEighty individuals with acute herpetic neuralgia (AHN) and 60 controls were recruited. The following nerve injury testing was performed on all of the patients including: the numerical rating scale (NRS) test, quantitative sensory testing (QST), and the investigation of serum NINJ2 levels on the 7th day of AHN; in addition, all of the patients repeated all of the items at 6 months after herpes.ConclusionsThe serum NINJ2 levels are associated with nerve injury, particularly with nerve recovery, and may be predictors of PHN occurrence.

Highlights

Herpes zoster and postherpetic neuralgia neuralgia(PHN) is the most common complication and is usually defined as pain lasting beyond 6 months after the onset of zoster [6, 7].Zoster results from the reactivation of endogenous varicella zoster virus (VZV), which persisted in the latent form within sensory ganglia following varicella [1, 2]
On the 7th day of acute herpetic neuralgia (AHN), the patients had significantly higher values of nerve injury induced protein 2 (NINJ2), cold-sense dispersion (∆CS), warm-sense dispersion (∆WS), cold-pain dispersion (∆CP), heatpain dispersion (∆HP) and numerical rating scale (NRS) score compared to controls
The serum NINJ2 levels are associated with nerve injury, with nerve recovery, and may be predictors of postherpetic neuralgia. β (PHN) occurrence

Summary

Introduction

Herpes zoster and postherpetic neuralgia neuralgia(PHN) is the most common complication and is usually defined as pain lasting beyond 6 months after the onset of zoster [6, 7].Zoster results from the reactivation of endogenous varicella zoster virus (VZV), which persisted in the latent form within sensory ganglia following varicella [1, 2]. Herpes zoster and postherpetic neuralgia neuralgia(PHN) is the most common complication and is usually defined as pain lasting beyond 6 months after the onset of zoster [6, 7]. Herpes zoster(HZ) typically begins with unilateral pain that persists for several days before the appearance of a rash [3]. It may manifest as throbbing pain, stabbing pain, burning pain, lancinating pain, and other types of pain, and is consistent with a skin lesion. The pain may occur accompanied by the rash or after the lesion heals [4]. Acute herpetic neuralgia (AHN) is defined as pain that occurs within 30 days after rash onset [5].

Objectives

Methods

Results

Conclusion