Abstract
Introduction Oxidative stress contributes to endothelial dysfunction and is involved in the pathogenesis of myocardial infarction (MI) and stroke. However, associations of biomarkers of oxidative stress with MI and stroke have not yet been addressed in large cohort studies. Methods A matched case-control design was applied in four population-based cohort studies from Germany, Czech Republic, Poland and Lithuania. Derivatives of reactive oxygen metabolites (d-ROM) levels, as a proxy for the reactive oxygen species (ROS) burden, and total thiol levels (TTL), as a proxy for the reductive capacity, were measured in serum samples of 476 incident MI cases and 454 incident stroke cases as well as five controls per case individually matched by study center, age and sex. Statistical analyses were conducted with multi-variable adjusted conditional logistic regression models. Results d-ROM levels were associated with both MI (odds ratio [OR]: 1.21 [95% confidence interval (CI): 1.05–1.40] for 100 Carr units increase) and stroke (OR: 1.17 [95% CI: 1.01–1.35] for 100 Carr units increase). TTL were only associated with stroke incidence (Quartiles 2–4 vs. quartile 1: OR: 0.79 [95% CI: 0.63–0.99]). The noted relationships were stronger with fatal than with non-fatal endpoints and the associations of TTL with fatal MI was statistically significant (OR: 0.69 [95% CI: 0.51–0.93] for 100 μmol/L-increase). Conclusions This pooled analysis of four large cohort studies suggests an important contribution of an imbalanced redox system to the etiology of mainly fatal MI and stroke events.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.