Abstract
Introduction: Both diabetes mellitus and hypertension are aspects of metabolic syndrome. Objectives: The aim of this study was to determine the relationship between serum magnesium level with resistant hyperlipidemia in a group of diabetic and hypertensive patients. Patients and Methods: The present cross-sectional study was carried out on 90 hypertensive and diabetic patients who referred to outpatient university clinic in Shahrekord (45 hypertensive and 45 diabetic patients). Included patients had high triglyceride levels despite 8 weeks of treatment with lipid-lowering agents. Results: There was an inverse significant relationship between serum magnesium and triglyceride levels in diabetic patients (P=0.002, r=-0.458), however, this correlation was not significant in hypertensive patients (P=0.754, r=0.048). Conclusion: This study showed, serum magnesium may affect triglycerides levels in diabetic patients, however, our finding requires further investigation with larger population.
Highlights
IntroductionObjectives: The aim of this study was to determine the relationship between serum magnesium level with resistant hyperlipidemia in a group of diabetic and hypertensive patients
Both diabetes mellitus and hypertension are aspects of metabolic syndrome
A total of 5 cc blood samples was taken from the patients after obtaining their consent letter, blood cholesterol, triglyceride, high-density lipoproteins (HDL)-C, low density lipoprotein (LDL-C), fasting blood glucose, and serum magnesium level were measured by standard methods
Summary
Objectives: The aim of this study was to determine the relationship between serum magnesium level with resistant hyperlipidemia in a group of diabetic and hypertensive patients. Results: There was an inverse significant relationship between serum magnesium and triglyceride levels in diabetic patients (P = 0.002, r = -0.458), this correlation was not significant in hypertensive patients (P = 0.754, r = 0.048). There are many lipoprotein disorders in patients with uncontrolled diabetes These metabolic disorders are due to the excessive production of triglyceride-rich lipoproteins of the liver, which is due to low levels of high-density lipoproteins (HDL). These patients suffer from hypertriglyceridemia, which is due to a decrease in adipose tissue and lipoprotein lipase activity in the muscle tissues. Can result in significant problems and increases the risk of cardiac and renal disease, stroke and death [3,4]
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