Abstract
Background : Magnesium (Mg++) deficiency is associated with poor glycemic control and Mg++ supplementation lowers blood sugar, improves insulin sensitivity and delays diabetic complications such as diabetic nephropathy, diabetic neuropathy, diabetic retinopathy. Objective : This study was designed to know the status of serum Mg++ in type 2 diabetic subjects with microalbuminuria and normoalbuminuria.Methodology : This study was conducted at the Department of Laboratory Medicine (Clinical Pathology) in collaboration with BIRDEM General Hospital, Dhaka. In this study, serum magnesium level and urine microalbumin level of 120 newly detected type 2 diabetic patients were measured. Both levels were measured by biochemical auto analyzer (Siemens Dimension RL Max).Result : The mean microalbumin level was found 22.9±3.1 mg/L with range from 2-105 mg/L and the mean magnesium level was found 1.9±0.3 mg/dl with range from 1.5-2.4 mg/dl. Pearson’s correlation coefficient was -0.353 between serum magnesium level and urine microalbumin which was statistically significant (p value < 0.05). Therefore, there was a linear negative correlation between serum magnesium level and urine microalbumin.Conclusion : The present study revealed negative correlation between serum magnesium level and urine microalbumin.Northern International Medical College Journal Vol.9(2) Jan 2018: 291-294
Highlights
Magnesium (Mg++) is the fourth most abundant cation in the human body.[1,2] One of the potential pathophysiological mechanisms linking serum magnesium to microalbuminuria is an amplification of insulin resistance
The present study revealed negative correlation between serum magnesium level and urine microalbumin
Another study has found that insulin deficiency or insulin resistance can affect the tubular absorption of magnesium, leading to hypomagnesemia in diabetic patients.[2]
Summary
Magnesium (Mg++) is the fourth most abundant cation in the human body.[1,2] One of the potential pathophysiological mechanisms linking serum magnesium to microalbuminuria is an amplification of insulin resistance. The level of intracellular calcium is increased in magnesium deficiency subjects. Mg++deficiency may cause endothelial cell dysfunction, inflammation and oxidative stress.[1] Endothelial cells could be injured through inflammatory response. Found that 25-39% of diabetics have low concentrations of serum magnesium.[7] Magnesium deficit in the diet would induce insulin resistance in humans.[2] If it is chronic, it may lead to macro-vascular and micro-vascular complications of diabetes. A low magnesium intake and an increased urinary loss of magnesium appear the most important mechanisms that may favor magnesium depletion in patients with type 2 diabetes.[1] Mg++intake is inversely longitudinally associated with the incidence of diabetes.[10] Approximately one-third of subjects with type 2 diabetis mellitus (DM) have hypomagnesaemia mainly caused by enhanced renal excretion. In this study,we try to find out the status of serum Mg++ in type 2 diabetic subjects with microalbuminuria and normoalbuminuria
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