Abstract
While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index (BMI), lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics (FIGO) grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age, BMI, triglyceride (TG), and high density lipoproteins (HDL) differed significantly among different stages of epithelial ovarian cancer (P<0.05). In the logistic regression model, elevated TG (OR: 1.883; 95% CI= 1.207–2.937), and low HDL (OR: 0.497; 95% CI= 0.298–0.829) levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development.
Highlights
Ovarian cancer is one of the most lethal gynecological malignancies worldwide, with an estimated 21,290 new diagnoses of ovarian cancer and 14,180 deaths anticipated for 2015 in the United States[1]
The logistic regression analysis model using a stepwise regression method indicated that TG (P < 0.05) was positively correlated with Epithelial ovarian cancer (EOC) severity, while high density lipoproteins (HDL) (P < 0.05) was negatively correlated with EOC severity (Table 4)
Our results demonstrate that TG was positively correlated with the severity of EOC, while HDL was negatively correlated with the severity of cancer
Summary
Ovarian cancer is one of the most lethal gynecological malignancies worldwide, with an estimated 21,290 new diagnoses of ovarian cancer and 14,180 deaths anticipated for 2015 in the United States[1]. Epithelial ovarian cancer (EOC) accounts for 90% of ovarian cancer cases, with serous cancer accounting for the most common histology type[2]. Most women present with advanced-stage disease at the time of diagnosis, 15 January 2018, Epub 23 February 2018 CLC number: R737.31, Document code: A The authors reported no conflict of interests. Because of the multiple causes, scientists have not reached a consensus concerning the prevalence of EOC. A marker that could be associated with tumor progression is necessary[4]
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