Association of serum glucose/potassium index levels with poor long-term prognosis in patients with Aneurysmal Subarachnoid Hemorrhage

Abstract

IntroductionThe glucose/potassium index (GPI) has been reported as a predictor biomarker of in-hospital complications in patients with aneurysmal subarachnoid hemorrhage (aSAH). ObjectivesTo determine the association between GPI and functional outcome at 3–6 months after discharge in patients diagnosed with aSAH in a Peruvian referral hospital during 2018–2021. Materials and MethodsWe conducted a retrospective cohort observational study with a secondary database in patients with aSAH during 2018–2021 in a Peruvian referral hospital. We evaluated the relationship between GPI values and motor functionality from 3 m to 6 months post-discharge, using a Poisson family generalized linear model with Log link function and robust variance according to categorization of good and poor outcome. We considered a value of p<0.05 as statistically significant. We used restricted cubic splines with five nodes to evaluate the linear correlation between the 2 main variables. Results212 patients were included in the analysis. 21.1 % and 19.3 % had poor outcome at 3 and 6 months after discharge, respectively. Multivariate analysis showed that GPI was not associated with poor outcome at 3 (RR=0.999; 95 %CI=0.979–1.018) or 6 months after discharge (RR=0.979; 95 %CI=0.979–1.020). On the other hand, Splines plots showed no correlation between GPI and modified Rankin. ConclusionsDespite the usefulness of GPI to prognosticate in-hospital complications, its association with functional outcome is inconclusive.