Association of Serum Gamma-Glutamyl Transferase with Metabolic Syndrome

Abstract

Background: Association between serum GGT and metabolic syndrome highlights the potential role of GGT as a biomarker in the early identification and management of this complex disorder. Further research is needed to elucidate the underlying mechanisms linking GGT and metabolic syndrome and to determine the clinical utility of GGT measurements in routine practice. Nonetheless, GGT holds promise as a valuable tool for assessing metabolic health and improving risk assessment in individuals at risk of metabolic syndrome. Objective: To assess the Association of Serum Gamma-Glutamyl Transferase with Metabolic Syndrome. Method: This Cross-sectional study was carried out at Outpatient department of Medicine, BSMMU, Shahbagh, Dhaka from March 2020 – July 2021. By non-probability sampling technique 36 diagnosed metabolic syndrome patients, 36 normal healthy subjects will be enrolled in the study. The purpose and procedure of the study was explained in detail and informed written consent was be taken from all the study subjects. Results: During the study, the mean values of Blood pressure, fasting plasma glucose, were increased from the first quartile to the fourth quartile (p <0.05). However, there were no significant differences observed in terms of age, waist circumference, LDL-C, HDL-C, total cholesterol, and BMI (p >0.05). A positive correlation was observed among Serum GGT, TG, fasting plasma glucose & blood pressure (p<0.05). A moderate positive correlation was observed between Serum GGT and waist circumference. However, there was no significant correlation with HDL cholesterol (p>0.05). Serum GGT is mainly influenced by levels of triglyceride (β= 0.238, t= 2.002, p= 0.049) and fasting plasma glucose (β=0.355, t= 2.980, p= 0.004). Logarithmic transformations of GGT, TG, and FPG were done to make the values normally distributed before conducting regression analysis. Conclusion: This study suggests that serum GGT is raised in metabolic syndrome group and GGT level .......