Association of serum gamma glutamyl transferase with lipid abnormalities in end stage renal disease

Abstract

Abstract Background End stage renal disease (ESRD) is characterized by high degree of mortality and cardiovascular complications. These complications occur due to many metabolic and endocrinal disturbances and dyslipidemia is the constant feature of ESRD. Oxidative stress is the final pathway mediating cardiovascular damage. There is evidence that GGT plays very important role in antioxidant defense system. Hence dyslipidemia and oxidative stress are predominant features of ESRD, which in long term predispose to cardiovascular complications. Objectives of our study were to estimate and to correlate lipid profile and GGT levels in ESRD patients on hemodialysis and healthy controls. Methods A case–control study was conducted in patients attending Nephrology unit of hospital. After obtaining informed consent, 45 patients who were clinically and biochemically diagnosed of ESRD between 25 and 60 years of age and undergoing hemodialysis were included as cases. Age of 70 and sex matched normal healthy volunteers from hospital staffs or patient attenders were included as controls. Serum lipid profile and GGT were estimated in all the study groups. Results Mean values of serum total cholesterol, triglycerides, LDL and GGT were significantly elevated in ESRD patients on hemodialysis. Serum HDL was significantly decreased in patients when compared to controls. We did not find any significant association of GGT with lipid parameters. Conclusion ESRD is associated with dyslipidemia and oxidative stress which predispose to adverse cardiovascular complications. However in our study no significant correlation between GGT levels and lipid parameters was observed.