Association of Serum Ferritin and Inflammatory Biomarkers with Insulin Resistance in Chinese Type 2 Diabetes Mellitus Patients

Pratiksha Paudel ,Shitian Zhang ,Aili Yin ,Bei Guo ,Bharvi Desai ,Liming Chen ,Chunmei Gu ,Gajarishiyan Rasalingam ,Ranjita Sah ,Alisha Pannu ,Yuhua Yuan ,Wen-Yan Niu

doi:10.37871/jbres1167

Abstract

Objective: Obesity-induced Insulin Resistance (IR) is one of the main causes of Type 2 Diabetes Mellitus (T2DM) and accompanies the progression of T2DM. Serum Ferritin has been shown to be associated with IR. Inflammation is also suggested to be involved in IR and pancreatic β-cell dysfunction. However, there is lack of enough evidence concerning the interrelationship between serum Ferritin, inflammation, and IR in the Chinese population with T2DM. In this study, the relationships between serum Ferritin and inflammatory biomarkers with IR in Chinese population were investigated. Methods: This cross-sectional study was conducted with 207 Chinese participants, aged 40-60 years in Tianjin, China. Serum Ferritin, transferrin, and folate were measured by immuno-assay analyzer. The levels of TNF-α, IL-1β, and IL-6 were detected by ELISA. IR was evaluated by Homeostasis model assessment (HOMA) of IR. Correlations were examined by regression analyses. Results: Serum Ferritin level was higher in non-diabetic obese and diabetic group than the non-diabetic lean group. The levels of TNF-α and CRP were significantly higher in the diabetic obese group than non-diabetic and diabetic lean subjects. Serum Ferritin, TNF-α, and CRP were all correlated with BMI. TNF-α correlated with IR and FPI. TNF-α, IL-6, IL-1β, and CRP were all correlated with FPG and HbA1c. Conclusion: In Chinese population, IR had a significant association with TNF-α but not with serum Ferritin. Serum Ferritin, TNF-α, and CRP were all correlated with BMI. Inflammation and glucose metabolism factors (FPG, HbA1c) showed a strong correlation with each other as well as with adiposity.

Highlights

Due to rapid economic growth and significant alterations in dietary habits, China houses the largest population suffering from Type 2 Diabetes Mellitus (T2DM) [1]
Serum Ferritin, TNF-α, and C-Reactive Protein (CRP) were all correlated with Body Mass Index (BMI)
In Chinese population, Insulin Resistance (IR) had a significant association with TNF-α but not with serum Ferritin

Summary

Introduction

Due to rapid economic growth and significant alterations in dietary habits, China houses the largest population suffering from Type 2 Diabetes Mellitus (T2DM) [1]. WHO reported that around 110 million Chinese suffered from T2DM in 2016, which is projected to increase up to 150 million by 2040 [2]. Around half of the country’s population (i.e. 500 million) currently lives with pre-diabetes, placing them at a risk of developing T2DM and related chronic disorders such as cardiovascular diseases [2]. T2DM is a group of chronic metabolic disorders characterized by abnormally increased levels of blood glucose for a prolonged period due to impaired insulin secretion and/or action. Alleviated cell sensitivity to insulin leads to inadequate absorption and ineffective utilization of glucose, resulting in hyperglycaemia. Pancreatic -cells secrete more insulin as a compensatory mechanism, leading to hyperinsulinemia. In China, as much as in the rest of the world, the obesity epidemic is growing at an alarming rate

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Conclusion