Abstract
Objectives:To investigate the association of serum chemerin with calcium, alkaline phosphatase and bone mineral density in postmenopausal non-osteoporotic and osteoporotic females.Methods:This cross-section analysis was carried out at the orthopedic department of Madina Teaching Hospital, Faisalabad, Pakistan, in the year 2017-2019. Postmenopausal females were divided into two groups according to their bone mineral density (BMD). All osteoporotic females had a T-score of -2.5 or less. Data were analyzed on SPSS-24.Results:A total of 140 women were included in our study (80 osteoporotic and 60 non-osteoporotic). Non significant difference in age and BMI was observed between osteoporotic and non-osteoporotic subjects (p=0.152) and (p=0.291) respectively. There was a significant difference found in total BMD, serum chemerin levels between osteoporotic and non-osteoporotic subjects p<0.001 in both parameters. No significant correlation of serum chemerin was found with serum calcium, serum alkaline phosphatase and BMD in postmenopausal osteoporotic females (p=0.907), (p=0.318) (p=0.664) respectively. A significant negative correlation was found between serum alkaline phosphatase levels and total BMD in postmenopausal osteoporotic females (p=- 0.039). Linear regression analysis of serum alkaline phosphatase levels with total BMD showed no association between BMD and serum alkaline phosphatase levels (p=0.869).Conclusion:There is no association of serum chemerin with calcium, ALP and bone mineral density in non-osteoporotic and osteoporotic postmenopausal females.
Highlights
Chemerin is an adipokine that regulates the formation of fat cells from stem cells
Experimental evidence suggested that chemerin and its chemokine activation like receptor-1 (CMKLR1) receptor can play an important role in osteoblastogenesis, bone mineralization, and osteoclastogenesis inhibition.[3]
There was a significant difference found in total bone mineral density (BMD), serum chemerin levels between osteoporotic and non-osteoporotic subjects p
Summary
Chemerin is an adipokine that regulates the formation of fat cells (adipocytes) from stem cells. It is involved in the maturation of adipocytes. It is believed that Chemerin is involved in controlling the growth of adipocytes and the metabolism of glucose, but it modifies metabolic functions in mature adipocytes.[2] Besides, experimental evidence suggested that chemerin and its CMKLR1 receptor can play an important role in osteoblastogenesis, bone mineralization, and osteoclastogenesis inhibition.[3] Few studies have explored the associations in humans between circulating levels of chemerin and bone mineral density (BMD) or osteoporosis.[4,5,6] In one study, Pak J Med Sci March - April 2021 Vol 37 No 2 www.pjms.org.pk 384 inverse relationships between serum chemerin and lumbar BMD levels have been reported in obese postmenopausal women.[5] there is contradictory evidence since serum levels of chemerin were higher[7] or lower[4] relative to healthy control subjects in osteoporosis patients
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