Abstract
BackgroundRecent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) have diverse biological influences on the cardiovascular system. CTRP 3 is a member of the CTRP superfamily, which may play a pivotal role in the pathogenesis of coronary artery disease (CAD). Here, we investigated whether serum levels of CTRP 3 are associated with the prevalence and the severity of CAD.MethodsIn this study, 145 eligible participants were included who underwent coronary angiography. According to the result of the coronary angiography, all participants were divided into two groups: non-CAD group (n = 66) and CAD group (n = 79). The CAD group was further divided into single-vessel (n = 25), double-vessel (n = 30) and triple-vessel (n = 24) disease groups in line with different lesioned vessels of CAD. Plasma CTRP 3 concentration was determined by enzyme-linked immunosorbent assay (ELISA).ResultsSerum levels of CTRP 3 were significantly higher in CAD patients than in non-CAD patients (CAD: 56.68 ± 3.63 ng/ml, non-CAD: 44.10 ± 3.20 ng/ml, p < 0.01). Significant differences of CTRP 3 levels were also found between single-vessel group and triple-vessel group (single-vessel group: 44.80 ± 3.14 ng/ml, triple-vessel group: 75.07 ± 9.41 ng/ml, p < 0.005). Multiple logistic regression analysis revealed that CTRP 3 levels, together with HDL cholesterol and glucose, correlated with CAD.ConclusionsElevated serum CTRP 3 levels were closely related to the prevalence and severity of CAD, suggesting that it might be regarded as a novel biomarker for CAD.
Highlights
Recent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) have diverse biological influences on the cardiovascular system
We found that coronary artery disease (CAD) patients had significantly higher Body mass index (BMI), systolic Blood pressure (BP), fasting glucose and C1q/ tumor necrosis factor related protein-3 (CTRP 3) (Fig. 1) than non-CAD patients
There were no statistical differences in age, frequency of smokers, diastolic BP, triglyceride (TG), total cholesterol (TC), low density lipoproteincholesterol (LDL-c) between the two groups
Summary
Recent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) have diverse biological influences on the cardiovascular system. CTRP 3 is a member of the CTRP superfamily, which may play a pivotal role in the pathogenesis of coronary artery disease (CAD). We investigated whether serum levels of CTRP 3 are associated with the prevalence and the severity of CAD. Multiple pro-inflammatory cytokines including tumor necrosis factor-a (TNF-a) and IL-6 are up-regulated in cases of obesity and intensify the prevalence and the progression of CAD [5,6,7]. The complement C1q tumor necrosis factor related protein (CTRP) superfamily is a newly found cluster of. We conducted a study on serum CTRP 3 and the prevalence or severity of CAD
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