ASSOCIATION OF SERUM C-REACTIVE PROTEIN AND D-DIMER CONCENTRATION WITH CLINICAL SEVERITY CAUSED BY CORONAVIRUS IN HOSPITALIZED PATIENTS WITH DIABETES

Abstract

BACKGROUND: The aim of this research was to compare the levels of inammatory markers (D-dimers and Creactive protein) in diabetic and non-diabetic patients depending on severity of clinical manifestation, therefore based on such, dene them as potential predictors of lethal outcome and clinical severity. A total of 422 subjects were included in this METHODS: research by retrospective review of the documentation at the Clinic for Infectious Diseases of University Clinical Hospital Mostar. While reviewing the medical records, the following data were lled in: demographic (age, sex, diabetes mellitus), oxygen saturation and paO2/O2 ratio, inammatory markers (C-reactive protein and D-dimers), used therapy (non-invasive ventilation, oxygen therapy, invasive mechanical ventilation) and nal outcome of disease. Based on the presence of diabetes mellitus the patients were divided into two groups: diabetic and nondiabetic patients. Data entry into tables was followed by statistical data processing using IBM SPSS Statistics v.26 and Microsoft Excel 2016. RESULTS: Out of total number of subjects, 161 had diabetes and 261 did not. Surprisingly, women statistically had a higher average value of Ddimers in comparison to men and they had a higher percetage of lethal outcome compared to men. Deceased patients had a higher average value of CRP (126,25) and D-dimers (2,20) in comparison to survivors. Also, the deceased had a lower average of oxygen saturation (83,07), lowered paO2/O2 ratio (131,5) and more liters of oxygen used in oxygen therapy (11,59). Statistically signicant higher lethality was noted in patients with diabetes compared to non-diabetic patients. Levels of C-reactive protei CONCLUSION: n and D-dimers were higher in patients with a more severe clinical manifestation. Since lethal outcome was more statistically prevalent in those subjects, CRP and D-dimers are stated as prognostic factors of clinical severity and lethal outcome in patients with COVID-19. Lastly, there was no notably increased difference in CRP and D-dimer levels between diabetic and non-diabetic patients.