Association of Serum Anti-Mullerian Hormone Level with Age in Subfertile Patients

Abstract

Introduction: Infertility affects approximately 10%-15% of reproductive-aged couples. Ovarian reserve describes the number of good-quality oocytes remaining within the ovaries. As a women ages, her ovarian reserve declines, principally due to apoptotic loss of primordial follicles. Serum AMH level is being considered a possible testing method for determining ovarian reserve. The aim of the study was to observe any association between serum Anti- Mullerian Hormone (AMH) level with patient age among subfertile patients. Methods: This cross-sectional observational study was conducted at the Department of Obstetrics and Gynaecology, Infertility Unit, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study duration was 14 months, from October 2011 to December 2012. The present study was conducted with 86 women of the reproductive age group with subfertility. Result: There was a gradual linear decline of AMH observed with an increment of age. The mean value of FSH and LH gradually increased in the higher age groups of 40-45 years than in the lower age group of 21-30 years. The mean BMI levels were almost similar in all age groups, and no remarkable difference could be discerned. The difference in AMH levels among the different age groups was statistically significant. a statistically significant negative correlation between age and serum AMH was observed, while a significant positive correlation was observed between FSH and age. Conclusion: As the age of a women advances, the AMH level decreases. The serum AMH is negatively correlated with age and serum FSH is positively correlated with age.