Association of serum adipocyte fatty acid-binding protein and apolipoprotein B /apolipoprotein A1 ratio with intima media thickness of common carotid artery in dyslipidemic patients.

Jiri Orsag,Veronika Kubickova,Helena Vaverkova,Milan Halenka,Jiri Lukes,David Karasek,Jaromira Spurna,Josef Zadrazil

doi:10.5507/bp.2018.043

Jiri Orsag, Veronika Kubickova + Show 6 more

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https://doi.org/10.5507/bp.2018.043

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Journal: Biomedical Papers	Publication Date: Sep 11, 2018
Citations: 2	License type: CC BY 4.0

Affiliation: University Hospital Olomouc

Abstract

Diseases caused by atherosclerosis play the most important role in mortality and morbidity worldwide. Serum adipocyte fatty acid binding protein (A-FABP) seems to be a new promising marker to determine the risk of atherosclerosis. The aim of this study was to evaluate relationships between serum A-FABP levels in studied individuals and to assess the possibility of modeling the intima media thickness of the common carotid artery (C-IMT) using A-FABP levels and other observed characteristics. Seventy two Caucasian individuals were enrolled and divided into 3 groups: dyslipidemic patients with or without metabolic syndrome (MetS+, n=17; MetS-, n= 34) and controls (n=21). There was confirmed the well-established risk profile of individuals with MetS (unfavorable lipid and lipoprotein profile, as well as increased parameters of insulin resistence and C-IMT). A-FABP concentrations in this group were significantly higher in comparison with both MetS- and controls. Using multiple linear regression models of C-IMT values for all individual data, healthy controls and dyslipidemic patients without metabolic syndrome (MetS-) A-FABP levels were not revealed as an important predictor of C-IMT in our model. In contrast, age, gender, waist circumference, nonHDL cholesterol levels and ApoB/ApoA1 ratio were important repressors of C- IMT in study individuals. This finding may be attributed to the overwhelming effect of other more robust risk factors for atherosclerosis in these individuals.

Highlights

Diseases caused by atherosclerosis such as stroke or myocardial infarction play the most important role in mortality and morbidity worldwide, especially in highly developed countries
Serum adipocyte fatty acid binding protein (A-FABP) seems to be a new promising marker to determine the risk of atherosclerosis
A-FABP concentrations in this group were significantly higher in comparison with both metabolic syndrome (MetS)- and controls

Summary

Introduction

Diseases caused by atherosclerosis such as stroke or myocardial infarction play the most important role in mortality and morbidity worldwide, especially in highly developed countries. Adipocyte fatty acid-binding protein (A-FABP) is a member of the fatty acid binding protein super family, accounting for approximately 6% of total cellular proteins in mature adipocytes[1] It is present in macrophages, which possess similar functions to adipocytes, modulated by proliferator-activated receptor-c agonists and oxidized low density lipoproteins[2]. Using multiple linear regression models of C-IMT values for all individual data, healthy controls and dyslipidemic patients without metabolic syndrome (MetS-) A-FABP levels were not revealed as an important predictor of C-IMT in our model. Age, gender, waist circumference, nonHDL cholesterol levels and ApoB/ApoA1 ratio were important repressors of C- IMT in study individuals. This finding may be attributed to the overwhelming effect of other more robust risk factors for atherosclerosis in these individuals

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