Abstract
Objective To investigate the correlation between serum levels of 25 hydroxyvitamin D and immunoglobulin E(IgE) in adults. Methods There were 1 969 participants over the age of 19 were enrolled in this studied, serum total IgE, dermatophagoides farinae(Df)-specific IgE, and serum 25(OH)D levels were analyzed.Other variables included sex, age, body mass index, smoking history, and economic status were collected.Adjusted regression analysis was used to examine the independent association of 25(OH)D with serum IgE levels. Results The average serum 25(OH) D level of 1 969 patients was (18.0±6.5) μg/L, the prevalence of asthma, allergic rhinitis, and atopic dermatitis were 15.2%(299/1 969), 2.8%(63/1 969) and 3.0%(68/1 969) respectively, however, there was no significant difference in serum 25(OH) D levels in patients with allergic rhinitis.All subjects were divided into four groups according to the serum 25(OH)D level: Q1: less than and equal to 13.4 μg/L, Q2: more then and equal to 13.4 μg/L but less then and equal to 17.0 μg/L, Q3: more then and equal to 17.0 μg/L but less then and equal to 21.7 μg/L, and Q4: more than and equal to 21.8 μg/L.The median TIgE level increased with higher quartiles in the Kruskal-Wallis test.The prevalence of Df in Q1, Q2, Q3, Q4 group were 39.8%, 33.2%, 38.7% and 43.1%, respectively.Linear regression analysis indicated that 25(OH) D levels were positively correlated with lgTIgE (regression coefficient: 0.011, 95%CI 0.001-0.021), 25(OH)D in male patients with dust mite allergy was positively correlated with lgTIgE(regression coefficient: 0.026, 95%CI 0.010-0.043). There was no significant correlation between 25(OH)D and lgTIgE in the other groups. Conclusion Adult serum 25 (OH) D levels is positively correlated with total IgE levels. Key words: 25 hydroxy vitamin D; Immunoglobulin E; Association; Adults
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