Association of serum 25-hydroxyvitamin D status with bone mineral density in 0-7 year old children.

Yanrong Fu,Juhua Yan,Chenbo Ji,Juan Wen,Heyun Lv,Wen Zheng,Mei Zhu,Yufei Ni,Aiping Wu,Guoqin Liu,Yan Zhao,Yarong Wei,Hongni Yue,Rui Qin,Xirong Guo,Hong Hong,Yinfang Li,Yuan Shi ,Guan-Yu Liang ,Yong Hu ,Zhenghong Yang ,Zhen-Ying Qin

doi:10.18632/oncotarget.13097

Abstract

ObjectiveTo describe the status of serum 25-hydoxyvitamin D [25(OH)D] concentrations and identify the relationship between 25(OH)D and bone mineral density (BMD). In an effort to explore the appropriate definition of vitamin D (VD) deficiency in 0–7 year old children.ResultsThe median serum 25(OH)D concentrations was 62.9 nmol/L and 28.9% of the children had a low 25(OH)D (< 50 nmol/L). And a linear relation between 25(OH)D concentrations and BMD was surveyed (r = 0.144 , P < 0.001). After adjusting for the confounders, serum 25(OH)D was positively associated with BMD (β = 172.0, 95%CI = 142.8–201.2, P < 0.001), and low 25(OH)D (< 75 nmol/L) had a high stake for low BMD (OR = 1.424, 95%CI = 1.145–1.769, P = 0.001). Additionally, there was a nonlinear relation between 25(OH)D and low BMD, and a critical value for 25(OH)D of 75 nmol/L appeared for low BMD. The prevalence of low BMD was 14.1% in children with 25(OH)D ≥ 75 nmol/L, much lower than that of the concentrations between 50–75 nmol/L and < 50 nmol/L.Materials and MethodsA total of 4,846 children 0–7 years old were recruited in Jiangsu Province, China. BMD and serum 25(OH)D concentrations were determined by quantitative ultrasound and enzyme-linked immunosorbent assay, respectively. Linear regression and logistic regression analyses were used to assess the association of 25(OH)D concentrations with BMD.ConclusionsSerum 25(OH)D concentrations was related with BMD and 25(OH)D concentrations < 75 nmol/L might be a more appropriate definition of VD deficiency in 0–7 year old children.

Highlights

Vitamin D (VD) deficiency is common among children due to the combined effects of additional growth needs, inadequate intake and limited sunlight exposure, which has become an grave public health issue in developed and developing countries [1]
After adjusting for the confounders, serum 25(OH)D was positively associated with bone mineral density (BMD) (β = 172.0, 95%CI = 142.8–201.2, P < 0.001), and low 25(OH)D (< 75 nmol/L) had a high stake for low BMD (OR = 1.424, 95%CI = 1.145–1.769, P = 0.001)
Serum 25(OH)D concentrations was related with BMD and 25(OH)D concentrations < 75 nmol/L might be a more appropriate definition of VD deficiency in 0–7 year old children

Summary

Introduction

Vitamin D (VD) deficiency is common among children due to the combined effects of additional growth needs, inadequate intake and limited sunlight exposure, which has become an grave public health issue in developed and developing countries [1]. Nowadays VD deficiency is severe among children in China, with a reported prevalence of 30%–70% in the north [2] and 10%–40% in the south of China [3, 4]. Since the 1920s, VD was identified and its deficiency was linked to rickets [7] and more and more studies showed that VD deficiency was associated with low BMD [8,9,10,11]. With the extensive researches and global emphasis on the importance of supplement, nearly 30 years ago, the appearance of serious nutritional rickets was considered to vanish [12], low BMD remained prevalent [8, 10, 13]. It is essential to maintain sustained circulating VD and bone mass from childhood to avoid these ricks

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