Association of sarcopenia with a higher risk of infection in patients with type 2 diabetes.

Abstract

This study aimed to determine whether patients with type 2 diabetes and sarcopenia had a higher risk of infection. A cross-sectional study and a follow-up study were performed. A total of 2562 patients were enrolled and assessed for body composition and infection status. They were classified into four groups according to body fat (BF) and muscle mass index (ASMI): obese, sarcopenic, sarcopenic obese, and normal. Among these, 275 patients were followed for a median follow-up period of 1.84 years to evaluate the relationship of changes in skeletal muscle with infection status. The sarcopenic and sarcopenic obese groups showed a higher risk of infection, an increase by 49.6% (OR=1.496, 95% CI 1.102-2.031) and 42.4% (OR=1.424, 95% CI 1.031-1.967) compared with the normal group, and also had a higher risk of respiratory infection, an increase by 56.0% (OR=1.560, 95% CI 1.084-2.246) and 57.4% (OR=1.574, 95% CI 1.080-2.293), respectively. Patients with the increased ASMI (OR=0.079, 95% CI 0.021-0.298) represented a lower risk of infection than those with the decreased ASMI. Even a minor change (OR=0.125, 95% CI 0.041-0.378) against age was beneficial to lowering the risk of infection. However, no association was found in the changes of body mass index and BF with infection status. Sarcopenia, especially in patients with diabetes who are also obese, increases the risk of infection. Maintaining or improving muscle mass is expected to reduce infections.