Abstract
Polymorphisms within miRNAs binding sites are associated with miRNAs function. The aim of this study was to investigate the relationship between rs61764370 polymorphism within let-7 miRNA binding site in KRAS gene and the risk of lung cancer in Iranian population. This case-control study was conducted with 100 lung cancer patients and 100 healthy persons. The rs61764370 polymorphism was analyzed using PCR-RFLP technique and direct sequencing. We found a significant relationship between rs61764370 (T / G) polymorphism and lung cancer risk, the GT genotype (OR: 6.25; 95% CI = 2.605-15.00; P= 0.000) and G allele (OR: 5.25; 95% CI = 2.259-12.208; P= 0.000) were significantly associated with an increased risk of lung cancer. According to our findings, there is a significant relationship between the KRAS rs61764370 polymorphism and lung cancer risk in Iranian population and this polymorphism may be used as a marker in detection of lung cancer in the future.
Highlights
Polymorphisms within miRNAs binding sites are associated with miRNAs function
Our results indicate that there is a significant relationship between KRAS gene polymorphism T>G heterozygote TG genotype vs TT and lung cancer risk (GG+GT vs TT: OR=6.25, 95%CI= 2.60515.00, P=0.000)
According to the findings of this study, there is a significant relationship between the rs61764370 polymorphism and the risk of lung cancer; the genotype GT (OR: 6.25; 95% CI = 2.60-15.00) and G allele (OR: 5.25; 95% CI = 2.259–12.208) are significantly associated with an increased risk of lung cancer in the Iranian population
Summary
The aim of this study was to investigate the relationship between rs61764370 polymorphism within let-7 miRNA binding site in KRAS gene and the risk of lung cancer in Iranian population. Conclusion: According to our findings, there is a significant relationship between the KRAS rs61764370 polymorphism and lung cancer risk in Iranian population and this polymorphism may be used as a marker in detection of lung cancer in the future. Association of Rs61764370 polymorphism within let-7 microRNA-binding site with lung cancer in Iranian population. Health Sciences License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Considering the importance of KRAS gene and Let-7 in the development of cancers, we decided to investigate the association between this polymorphism and lung cancer risk in the Iranian population in this study
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