Association of rs2910164 Polymorphism in miRNA-146 and rs3746444 Polymorphism in miRNA-499 with Inflammatory Arthritis: A Meta-Analysis.

Dingjian Wang,Guixia Pan

doi:10.1155/2019/7305750

Abstract

Objectives The purpose of this study was to explore the association of miRNA-146 and miRNA-499 polymorphisms with inflammatory arthritis. Methods A systematic search of studies on the association of miRNA-146 and miRNA-499 polymorphisms with inflammatory arthritis susceptibility was conducted in PubMed, Web of science, Elsevier ScienceDirect, and Cochrane Library. Eventually, 18 published studies were included. The strength of association between miRNA-146/499 polymorphisms and inflammatory arthritis susceptibility was assessed by odds ratios (ORs) with its 95% confidence intervals (CIs). Results A total of 18 case-control studies, consisting of 3385 inflammatory arthritis patients and 4584 controls, were included in the meta-analysis. This meta-analysis showed significant association between miRNA-499 rs3746444 polymorphism and inflammatory arthritis susceptibility in overall population (C vs T, OR: 1.422, 95% CI= 1.159-1.745, P=0.001). Similar results were found in subgroup analysis by region. But we did not find association between miRNA-146 rs2910164 polymorphism and inflammatory arthritis susceptibility in overall population (C vs T, OR: 1.061, 95% CI= 0.933-1.207, P=0.365). Conclusions The present study indicates that miRNA-499 rs3746444 polymorphism is associated with inflammatory arthritis susceptibility. However, there is lack of association between miRNA-146 rs2910164 polymorphism and inflammatory arthritis susceptibility. But, we also find miRNA-146 rs2910164 and miRNA-499 rs3746444 polymorphism are associated with inflammatory arthritis in Middle East. Therefore, more large-scale studies are warranted to replicate our findings.

Highlights

Inflammatory arthritis is a group of complex diseases, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), juvenile idiopathic arthritis (JIA), etc
There is no doubt that environmental factors and genetic factors play an important role in the development of inflammatory arthritis
Metaanalysis indicated that there is lack of association between miRNA-146 rs2910164 polymorphism and inflammatory arthritis susceptibility in the overall population

Summary

Introduction

Inflammatory arthritis is a group of complex diseases, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), juvenile idiopathic arthritis (JIA), etc. It is characterized by inflammatory cell infiltration into the joints [1, 2]. MicroRNAs (miRNAs) are small noncoding RNAs, which are about 22 nucleotides long. They play an important role in regulating transcription and translation [3,4,5,6]. Some studies reported that miRNA may associate with inflammatory arthritis, such as miRNA-146 rs2910164 and miRNA-499 rs3746444. We chose miRNA-146 rs2910164 and miRNA-499 rs3746444 to explore the association between its polymorphisms and inflammatory arthritis

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Conclusion