Abstract
BackgroundGenome-wide association studies have reported that the 9p21.3 locus confers risk for coronary artery disease (CAD). However, it is not known whether rs10811656 is linked with CAD in a Chinese population. Thus, the purpose of this study was to investigate the potential association between rs10811656 and the risk of CAD in a Chinese population.MethodsWe conducted a hospital-based, case–control study with 251 CAD patients and 304 controls to examine the potential association of rs10811656 with CAD.ResultsThe frequencies of the TT genotypes in CAD cases were significantly different from those in controls (adjusted OR: 1.96, 95 % CI: 1.09–3.505, P = 0.024). Compared to controls, rs10811656 was significantly associated with the stable angina pectoris (adjusted OR: 1.42, 95 % CI: 1.06–1.90, P = 0.017), but not with acute coronary syndrome. There was also a highly significant association of rs10811656 with double-vessel and triple-vessel disease when patients were divided into subgroups based on the number of diseased vessels (adjusted OR: 1.68 and 1.60, 95 % CI: 1.14–2.44 and 1.10–2.33, P = 0.009 and 0.02, respectively).ConclusionOur results suggest that the rs10811656 locus might be associated with CAD in a Chinese Han population.
Highlights
Genome-wide association studies have reported that the 9p21.3 locus confers risk for coronary artery disease (CAD)
Genotypes and allele frequencies in CAD cases and controls and their associations with CAD The minor allele (T) frequency of rs10811656 was 0.3817, and the genotype distribution in our study subjects showed no deviation from the Hardy–Weinberg equilibrium (P > 0.05)
We did not observe a significant relationship between the rs10811656 T allele and acute coronary syndrome (ACS), we found that the frequency of patients with T-variant genotypes increased from double- to triple-vessel disease, whereas there was no association with single-vessel disease
Summary
Genome-wide association studies have reported that the 9p21.3 locus confers risk for coronary artery disease (CAD). Genome-wide association studies have shown that common variants in the 9p21.3 gene desert might be robustly associated with the risk of CAD, acute coronary syndrome (ACS), early atherosclerosis, abdominal aortic aneurysm, and intracranial aneurysm [5,6,7], the mechanisms underlying these associations are not completely understood. It remains unknown whether rs10811656 polymorphism in this region might be linked with the risk of CAD
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