Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development.

Wei-Hung Yang,Chen-Ming Su,Yung-Sen Chang,Shoou-Jyi Wang,Chih-Hsin Tang,Shun-Fa Yang

doi:10.1155/2018/9531315

Abstract

Oral squamous cell carcinoma (OSCC) accounts for over 90% of malignant neoplasms of the mouth. In Taiwan, OSCC is the fourth most common male cancer and the fourth leading cause of male cancer death. Resistin (RETN) is an adipokine that is associated with obesity, inflammation, and various cancers. Here, we examine the association between four single nucleotide polymorphisms (SNPs) of the RETN gene (rs3745367, rs7408174, rs1862513, and rs3219175) and OSCC susceptibility as well as clinical outcomes in 935 patients with OSCC and in 1200 cancer-free healthy controls. We found that, in 1465 smokers, RETN polymorphisms carriers with the betel-nut chewing habit had a 6.708–10.882-fold greater risk of having OSCC compared to RETN wild-type carriers without the betel-nut chewing habit. Patients with OSCC who had A/A homozygous of RETN rs3219175 polymorphism showed a high risk for an advanced tumor size (> T2), compared to those patients with G/G homozygotes. In addition, A/T/G/G haplotype significantly increased the risks for OSCC by 1.376-fold. This study is the first to examine the risk factors associated with RETN SNPs in OSCC progression and development in Taiwan.

Highlights

Oral squamous cell carcinoma (OSCC) accounts for over 90% of malignant neoplasms of the mouth [1]
After adjusting for potential confounders, we found no significant differences in the incidences of OSCC patients with the rs3745367, rs7408174, rs1862513, and rs3219175 polymorphisms compared to controls
RETN polymorphisms have been identified in various cancers, including colon, breast, and lung [16, 18, 19], scant data exist on the involvement of RETN polymorphisms in OSCC

Summary

Introduction

Oral squamous cell carcinoma (OSCC) accounts for over 90% of malignant neoplasms of the mouth [1]. In Taiwan, OSCC is the fourth most common male cancer and the fourth leading cause of male cancer death [2]. Despite combination treatment with radiation, surgery, and chemotherapy, the prognosis of OSCC remains poor [3, 4]. OSCC occurs through multiple genetic alterations due to chronic exposure to environmental carcinogens. Alcohol and tobacco consumption, betel quid chewing, and viral infection are all implicated as risk factors for OSCC [5,6,7]. Single nucleotide polymorphisms (SNPs) constitute the most common type of DNA sequence variation influenced gene expression and protein production and function as well as disease susceptibility in particular individuals [8, 9]

Methods

Results

Conclusion