Abstract

Objective To investigate the association of renal function and inflammatory cytokines with left ventricular hypertrophy (LVH) in patients with intermediate or advanced stage chronic kidney disease (CKD).Methods Fifty-one hospitalized or clinic patients with intermediate or advanced stage CKD registered to our hospital between January 2009 and December 2012 were enrolled.Clinical and biochemical data of these patients were recorded.Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) of these patients were measured with ultrasonography and used for calculation of left ventricular mass index (LVMI).The patients were then divided into stage Ⅲ CKD group or stage Ⅳ CKD group according to glomerular filtration rate (GFR),and also into LVH group and non-LVH group according to presence of LVH.Clinical and biochemical data,as well as findings of ultrasonography were compared between these groups.The correlation between GFR and the clinical and biochemical data,ultrasonic findings were analyzed.Results Of all 51 CKD patients,32 were stage Ⅲ CKD,and 19 stage Ⅳ CKD.There were no statistical difference in serum C-reactive protein (CRP),fibrinogen and albumin between patients with stage Ⅲ and stage Ⅳ CKD (all P＞0.05).A total of 40 patients had LVH and the remaining 11 did not.Compared with non-LVH group,patients in LVH group had higher levels of serum CRP and fibrinogen,and lower level of serum albumin (all P ＜ 0.05).In intermediate or advanced stage CKD patients,GFR correlated positively with LVEF and LVFS (r=0.398 and 0.394,respectively,both P ＜ 0.05).Conclusions In patients with intermediate or advanced CKD,higher levels of serum CRP and fibrinogen may predict the occurrence of LVH.The renal function in those patients is associated with left ventricular systolic function. Key words: Kidney diseases; Glomerular filtration rate; Inflammation; Hypertrophy, left ventricular

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