Abstract
Objective:Alterations in common DNA repair genes (RAD51 and XRCC2) may lead to cervical cancer (CC) development. In the present study, we analyzed the association between RAD51 rs1801320 and XRCC2 rs3218536 polymorphisms and CC. Methods:Variants were selected based on their associations with some cancers in several ethnicities and the risk allele frequency (>0.05) in different populations. The variants were detected using the PCR-RFLP method. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) were determined by logistic regression models. Result:Significantly increased risk (p<0.05) were detected for both SNPs with CC (rs1801320- GC vs. GG: aOR=2.21, 95% CI=1.43-3.42; CC vs. GG: aOR=4.48, 95% CI=1.76-11.42; dominant model: aOR=2.49, 95% CI=1.65-3.76; recessive model: aOR=3.52, 95% CI=1.40-8.88; allele model: OR=2.30, 95% CI=1.63-3.26, and rs3218536- GA vs. GG: aOR=2.77, 95% CI=1.85-4.17; AA vs. GG: aOR=5.86, 95% CI=2.08-16.50; dominant model: aOR=2.97, 95% CI=1.99-4.42; recessive model: aOR=3.56, 95% CI=1.30-9.73; and allele model: aOR=2.21, 95% CI=1.62-3.00). Besides, older patients (>60 years) with rs1801320 showed significantly reduced risk (OR=0.53, 95% CI=0.29-0.96, p=0.04) but with rs3218536 depicted significantly increased risk (aOR=2.44, 95% CI=1.20-4.96, p=0.01) for CC. Conclusion:This study indicates an association of rs1801320 and rs3218536 polymorphisms with CC and confirms that patients older than 60 years are more likely to develop CC for rs3218536 polymorphism.
Highlights
Cervical cancer (CC), a major female malignant disease developed in the cervix of women’s uterus, is the overall seventh and fourth most frequently appeared female cancer worldwide based on its incidence and mortality rate (Arbyn et al, 2020; Hamadani et al, 2017)
Despite the drastically increased incidence of cervical cancer, the precise reason for its development is unrevealed until today
Like in the case of all other cancers, the growth of cervical cancer is a consequence of reciprocal action between the genetic predisposition and environmental factors
Summary
Cervical cancer (CC), a major female malignant disease developed in the cervix of women’s uterus, is the overall seventh and fourth most frequently appeared female cancer worldwide based on its incidence and mortality rate (Arbyn et al, 2020; Hamadani et al, 2017). In 2018, nearly half a million CC patients (570,000 cases) were diagnosed with the death of 311,000 patients worldwide, while a larger number (approximately 80%) are from developing countries, including various Asian (southern, central and southeast regions), Caribbean and African countries with the highest mortality rate, mostly due to their delayed diagnosis (Hasan et al, 2021; Patil et al, 2018; Bray et al, 2018). Multiple molecular dysfunctions, along with the oncogenic activation or tumor suppressor gene inactivation, are necessary for CC formation (Settheetham-Ishida et al, 2020; Chen et al, 2017)
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