Abstract
The aim. Assessment of the initial psychological status of men with first diagnosed pulmonary tuberculosis and the study of its associations with the clinical course of the disease.
 Materials and methods. The study involved 54 men with first diagnosed pulmonary tuberculosis. Patients had a dynamic complex clinical, laboratory and instrumental examination with an assessment of the psychological status according to the State-Trait Anxiety Inventory (STAI) and the Beck Depression Inventory (BDI).
 Results. The evaluating of initial psychological status in patients with first diagnosed pulmonary tuberculosis, depressive states of varying severity were found in 47.05 % of patients, moderate state anxiety – in 74.51 % of patients, moderate trait anxiety – in 35.29 %. We revealed associations of the levels of anxiety and depression with the degree of bacterial excretion and the duration of the intensive phase of therapy.
 Conclusions. To assess the psychological status of patients with first diagnosed infiltrative pulmonary tuberculosis, it is advisable to use the STAI and the BDI.
 Patients with first diagnosed infiltrative pulmonary tuberculosis in 100 % of cases have psychological status disorders with a predominance of moderate state anxiety and the absence of depressive disorders in only half of them. More expressed violations of the psychological status (anxiety, depression) identifies patients who are married and have a steady job.
 In patients with first diagnosed infiltrative pulmonary tuberculosis, an increase in the severity of anxiety and depression is associated with more expressed bacterial excretion, decrease in body weight, greater frequency of destruction of lung tissue, prevalence of the tuberculosis process by more than 2 lung segments, decrease in the effectiveness of standard therapy and prolongation intensive phase of treatment.
Highlights
According to World Health Organization’s report 2019, tuberculosis has caused an estimated 1.4 million deaths
According to the results of a survey on the StateTrait Anxiety Inventory (STAI), it was found that the proportion of patients with low state an xiety (S-Anxiety) was 25.49 ± 6 % (n = 13)
After questioning patients on the Beck Depression Inventory (BDI), it was found that 52.94 ± 7 % of patients (n = 27) had no signs of depressive disorders, and 37.25 ± 7 % (n = 19) and 9.8 ± 4 % (n = 5) had respectively moderate and mild depression
Summary
According to World Health Organization’s report 2019, tuberculosis has caused an estimated 1.4 million deaths. Among the factors that can influence the development and course of tuberculosis infection, the psychological state of the patient may have a certain value [3]. It is assumed that the chances of developing tuberculosis are significantly increased in patients with depression at the background of a decrease of immune defences [6]. It is known that with the background of depression there is a suppression of cellular immunity factors activity and an increase of catecholamines, histamine, opioids and some pro-inflammatory cytokines expression, which negatively affect the susceptibility to tuberculosis infection [7]. The chronicity of the tuberculous process causes the progression of tissue hypoxia, contributing to the development of anxiety and depression [8]
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