Abstract
BackgroundAlthough numerous studies have been conducted to determine the relationship between psoriasis and thyroid dysfunction, contrasting results have been reported. The link between psoriasis and thyroid disease has not been elucidated well. This study aimed to determine the frequency of thyroid dysfunction and its relationship with gender, age, duration, and severity of psoriasis among patients with psoriasis.MethodologyPsoriasis was diagnosed clinically, and the severity of the disease was assessed by the Psoriasis Area Severity Index (PASI) score and the body surface area (BSA) involved, as measured by Wallace’s rule of nine. A total of 111 patients with psoriasis were analyzed for thyroid dysfunction, which included thyroid-stimulating hormone, free T3, free T4, and anti-thyroid peroxidase (anti-TPO) antibody levels. SPSS version 23.0 (IBM Corp., Armonk, NY, USA) was used for analysis.ResultsOut of the 111 analyzed psoriasis patients, deranged thyroid status was observed in 22 patients. Anti-TPO was increased in 19 patients. Patients with thyroid dysfunction had a more severe form of psoriasis (both by PASI score and BSA involvement) than those with mild psoriasis (61.9% vs. 38.1%), whereas patients with increased anti-TPO had a milder disease.ConclusionsThis study illustrated deranged thyroid status and thyroid autoimmunity in 19.8% and 17.1% of psoriasis patients, respectively, suggesting thyroid dysfunction and autoimmunity. However, further studies are required to expand our knowledge of psoriasis and its association with thyroid dysfunction and thyroid autoimmunity, as well as with age, gender, disease duration, and severity of psoriasis.
Highlights
Psoriasis is a chronic, immunologically mediated, proliferative skin disorder
Out of the 111 analyzed psoriasis patients, deranged thyroid status was observed in 22 patients
Patients with thyroid dysfunction had a more severe form of psoriasis than those with mild psoriasis (61.9% vs. 38.1%), whereas patients with increased anti-TPO had a milder disease
Summary
Various studies have revealed that autoimmune diseases are more prevalent in patients with psoriasis and psoriatic arthritis than in the general population. Autoimmune disorders linked with psoriasis include vitiligo, diabetes mellitus, autoimmune thyroiditis, rheumatoid arthritis, and inflammatory bowel disease. The exact link in the pathogenesis is not well understood, both AITD and psoriasis share several similar inflammatory pathways, which is possibly the connection between the two disorders. Our study intends to assess the frequency of thyroid dysfunction and thyroid autoimmunity in patients with psoriasis and determine the association among thyroid dysfunction, thyroid autoimmunity, and clinical features, including gender, age, duration, and. This study aimed to determine the frequency of thyroid dysfunction and its relationship with gender, age, duration, and severity of psoriasis among patients with psoriasis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
