Abstract
With the growing pandemic of COVID-19, psoriasis has been reported to be linked with COVID-19 from genetic and epidemiological perspectives, especially in patients receiving systemic treatments.1-3 However, traditional epidemiology is inevitably affected by confounding bias. Mendelian randomization (MR) is an approach based on genome-wide association studies to construct instrumental variables (IVs) and can effectively control the confounding bias of observational studies. IVs refer to variables that only affect the outcome through risk factors, and MR uses single-nucleotide polymorphisms as IVs to identify risk factors.
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