Abstract
Background. Prolactin (PRL) level is proposed to be associated with the severity of psoriasis although the previous studies reported different results. Objective. To find the association between PRL levels and severity of psoriasis before and after treatment. In addition, we aimed to find a difference in prolactin, thyroid stimulating hormone (TSH), thyroid hormones (T3 and T4), and cortisol levels between patients with psoriasis and normal controls. Methods. First, the levels of hormones were measured in 30 patients with psoriasis and 30 matched controls. The severity was assessed by psoriasis area and severity index (PASI). Then, patients were treated, and PASI was assessed every week until achieving PASI-75 response. At this time, the hormones were measured again and compared to the baseline. Results. No statistical significant difference was observed in the mean PRL, T3, T4, TSH, and cortisol levels between cases and controls. Comparing to the baseline, a significant decrease in PRL levels and a significant increase in T3 and serum cortisol levels were observed after treatment (P < 0.05), while the changes in other hormones were not significant. Conclusion. After treatment, PRL significantly decreased, and T3 and cortisol levels significantly increased. No correlation between hormone levels and improvement of PASI score existed.
Highlights
Psoriasis is a T-cell mediated autoimmune disease [1]
Existence of PRL receptors on epidermal keratinocytes provides more support for the hypothesis stating that PRL might have some role in the etiopathogenesis of psoriasis [4]
We designed a study to assess the association of the severity of psoriasis with changes in the plasma levels of prolactin, thyroid stimulating hormone (TSH), T3, T4, and cortisol in patients admitted to our university hospital from March 2011 through March 2012
Summary
Psoriasis is a T-cell mediated autoimmune disease [1]. Genetic, environmental, immune defect, and hormonal factors take part in autoimmune pathogenesis of diseases [2]. Some hormones may have role in pathogenesis of psoriasis due to their effects on keratinocytes proliferation; in vitro studies on prolactin (PRL) has demonstrated proliferative effect on keratinocytes, epithelial cells, and lymphocytes. Previous studies have assessed the association of PRL levels with the severity of psoriasis; the results are contradictory [5,6,7]. Prolactin (PRL) level is proposed to be associated with the severity of psoriasis the previous studies reported different results. We aimed to find a difference in prolactin, thyroid stimulating hormone (TSH), thyroid hormones (T3 and T4), and cortisol levels between patients with psoriasis and normal controls. Patients were treated, and PASI was assessed every week until achieving PASI-75 response At this time, the hormones were measured again and compared to the baseline. No correlation between hormone levels and improvement of PASI score existed
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