Association of Prx4, Total Oxidant Status, and Inflammatory Factors with Insulin Resistance in Polycystic Ovary Syndrome.

Sahar Mazloomi,Shamim Pilehvari,Nasrin Sheikh,Marzieh Sanoee Farimani

doi:10.1155/2021/9949753

Abstract

Introduction Chronic inflammation and oxidative stress conditions have been reported in women with polycystic ovary syndrome (PCOS). Peroxiredoxin 4 (Prx4) is a related antioxidant in insulin synthesis. We hypothesized that insulin resistance in these women is associated with total oxidant status (TOS) and inflammatory factors. Materials and Methods Two hundred three people including 104 PCOS patients and 99 healthy women, who were matched for age and body mass index (BMI), entered the study. Waist circumference of the participants was measured; serum glucose, lipid profile, insulin, Prx4, TOS, hs-CRP, and TNF-α were also evaluated. Results The Prx4 level was significantly lower in PCOS than in the control group. In addition, marked increase was observed in the concentration of TOS, hs-CRP, and TNF-α in PCOS, compared to the healthy women. There was a positive correlation of TOS with hs-CRP, TNF-α, and HOMA-IR. The risk of PCOS for subjects with high hs-CRP was 60 times greater than those who had low serum hs-CRP concentration; after performing multiple logistic regression analyses with the backward method, TNF-α was considered as an effective biomarker to predict PCOS β = 49.087 (all p < 0.05). Conclusion This study identified increased oxidative stress and inflammation in PCOS; this may be due to decrease in the antioxidants, such as Prx4.

Highlights

Chronic inflammation and oxidative stress conditions have been reported in women with polycystic ovary syndrome (PCOS)
Peroxiredoxin 4 (Prx4), total oxidant status (TOS), hs-C reactive protein (CRP), and tumor necrosis factor-α (TNF-α) Analysis. e level of Prx4 was significantly lower in PCOS 9.45 ± 0.302 ng/ml compared to the control group 10.52 ± 0.337 ng/ml (p 0.026). e mean TOS level was different in the patient group compared to the controls (8.66 ± 0.299 versus 3.52 ± 0.116 μmol Equiv/L, respectively, p < 0.001)
PCOS is a multifactorial disorder diagnosed by hyperandrogenism, polycystic ovary, and chronic anovulation in premenopausal women [2]

Summary

Introduction

Chronic inflammation and oxidative stress conditions have been reported in women with polycystic ovary syndrome (PCOS). We hypothesized that insulin resistance in these women is associated with total oxidant status (TOS) and inflammatory factors. Marked increase was observed in the concentration of TOS, hs-CRP, and TNF-α in PCOS, compared to the healthy women. Is study identified increased oxidative stress and inflammation in PCOS; this may be due to decrease in the antioxidants, such as Prx. Insulin resistance has been reported in 50–70% of women with PCOS; it is identified as an important risk factor to develop metabolic syndrome in the cited women [3, 4]. In PCOS patients, compared to healthy women, the level of inflammatory factors such as C reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukins (IL-1, IL6, and IL-18) increases [9, 10]. TNF-α has a role in PCOS patients with obesity and hyperandrogenism [13]

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