Association of Prothrombin G20210A Mutation with Unexplained Recurrent Pregnancy Loss

Abstract

Purpose: To assess the relationship of Prothrombin G20210A gene mutations as a risk factor for idiopathic repeated pregnancy loss. The focus has been on Prothrombin G20210 Amutation that may predispose women to microthrombosis during the stages of embryo implantation and placentation. Method: A total of 70 women with recurrent pregnancy loss, mean age 31.1±4.2 years, were involved in the study. As a control group, 70 women [mean age 32.2±3.3y ears with at least two live-born child and no history of abortion were included. We used real-time polymerase chain reaction (PCR) to determine the frequencies of Prothrombin G20210 Agenotype. Results: The frequency of heterozygotes for F2 was significantly higher in women with repeated pregnancy loss compared to women without abortion (p = 0.0001). Conclusion: In summary we found an association of prothrombin G20210A mutation with recurrent pregnancy loss .we recommend for prothrombin G20210A screening in cases with repeated pregnancy loss so they can start anticoagulant therapy more earlier