Association of Protein Expression P53 Mutants with Regional Lymph Gland Status on Type III of Nasofaring Patients in Carcinoma

Abstract

In nasopharyngeal epithelial cells, one of the malignant diseases that have been documented involved NPC (nasopharyngeal carcinoma). Through the mutant p53 gene, there is a cancer cell mutation process relative to the role of tumor suppressor genes. With poor prognosis linked to or characterizing enormous regional lymph nodes, the implication is that through the regional lymph gland status analysis, there tends to be a determination of the progression of NPC. In this study, the central objective lay in the mutant p53 protein’s expression analysis, relative to NPC. Specifically the clinical manifestation on the focus entailed N, which represented the status of the regional lymph gland. In the study, there was the implementation of the monoclonal rabbit anti human p53 clone 318-6-11. Its role involved incorporation in the immunohistochemical cracking method, meant for the NPC tissue paraffin block-based mutant p53 protein’s expression. Also, the Anatomical Pathology Consultant was implemented in a quest towards the visual assessment of microscope light binoculars. In the findings, relative to all subjects and samples, 57.58% was the value that was established in relation to the p53 mutants’ positive expression. These findings were for the case of the N0 sample, which exhibited 0 subjects. For other situations, 7 subjects were for N3, 7 subjects also for N2, and 6 subjects for N1. Withp> 0.05, the Mann-WhitneyU-Test test gave the value ofpas 0.706, implying that the correlation between regional lymph gland and p53 protein’s positive expression was not statistically significant. These results were documented after the study focused on type III WHONPC. In summary, the study established that in type III WHONPC, the relationship between lymph and regional gland and p53 mutant expression protein was not significant.