Abstract
Objective:Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10) gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10 gene with susceptibility to lung cancer. Methods:a comprehensive search of PubMed, EMBASE, and CNKI databases was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association. Results:A total number of 19 case-control studies with 4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR= 1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However, there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk. Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer among Asians and Caucasians. Conclusions:Our meta-analysis suggests that the IL-10 -592A>C polymorphism might be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G polymorphisms are not significantly associated with increased risk of lung cancer.
Highlights
Lung cancer is one of the most commonly diagnosed cancer (12.7% of the total cancer diagnoses) as well as the leading cause of cancer death (18.2% of the total cancer deaths) among all cancer patients worldwide (Mehrabi et al, 2017; Zhong et al, 2012)
Meta-analysis as a powerful tool can provide more reliable results than a single study especially in explaining controversial conclusions. We performed this meta-analysis with larger sample size and subgroup to achieve a better understanding of the association of promoter region polymorphisms of IL-10 gene with lung cancer risk
To the best of our knowledge, our meta-analysis, on the basis of 19 case-controls 4,084 cases and 6,131 controls is the largest and most comprehensive assessment to evaluate association of IL-10 with lung cancer and the final results showed that -592A>C polymorphism was associated with an increased lung cancer risk
Summary
Lung cancer is one of the most commonly diagnosed cancer (12.7% of the total cancer diagnoses) as well as the leading cause of cancer death (18.2% of the total cancer deaths) among all cancer patients worldwide (Mehrabi et al, 2017; Zhong et al, 2012). The mean onset age for lung cancer has been estimated ranged 60 to 70 years, less than 10% of all cases occurred at an early age (Rosenberger et al, 2008). Genetic factors involved in lung cancers have been extensively studied and to date several genetic polymorphisms have been identified as candidates by meta-analyses. Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) deleterious mutations occur mutually among 5-15% of lung cancer cases (Choughule et al, 2014). The promoter region polymorphisms of IL-10 gene has been associated with susceptibility to several cancers including lung cancer (Namazi et al, 2018; Sheikhpour et al, 2017). Published data on the possible association of IL-10 polymorphism with lung cancer have generated
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